X0306 4 2020-12-14 0 0001434418 CONSTELLATION PHARMACEUTICALS INC CNST 0001347769 COLUMN GROUP L P 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001668159 COLUMN GROUP III, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001668085 COLUMN GROUP III-A, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001790965 COLUMN GROUP III GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001614627 COLUMN GROUP GP, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001707230 PONOI CAPITAL, LP 1700 OWENS STREET SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001720702 Ponoi Management, LLC 1700 OWENS STREET, SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001732601 Ponoi Capital II, LP 1700 OWENS STREET, SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001746488 Ponoi II Management, LLC 1700 OWENS STREET, SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 0001614186 Kutzkey Tim 1700 OWENS STREET, SUITE 500 SAN FRANCISCO CA 94158 0 0 1 0 Common Stock 2020-12-14 4 X 0 30107 1.55 A 2584957 D Common Stock 1880623 I See Footnote Common Stock 1574229 I See Footnote Common Stock 19571 I See Footnote Common Stock 22103 I See Footnote Common Stock 159155 I See Footnote Warrant (right to buy) 1.55 2020-12-14 4 X 0 30107 0.00 D 2021-05-24 Common Stock 30107 0 D The securities are directly held by The Column Group, LP ("TCG LP"). The Column Group GP, LP ("TCG GP") is the general partner of TCG LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG GP are David Goeddel and Peter Svennilson (collectively, the "TCG Managing Partners"). The TCG Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG GP and each of the TCG Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. The securities are directly held by Ponoi Capital, LP ("Ponoi LP"). Ponoi Management, LLC ("Ponoi LLC") is the general partner of Ponoi LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of Ponoi LLC are David Goeddel, Peter Svennilson, and Tim Kutzkey (collectively, the "Ponoi Managing Partners"). The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. Ponoi LLC and the each of the Ponoi Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares The securities are directly held by Ponoi Capital II, LP ("Ponoi II LP"). Ponoi II Management, LLC ("Ponoi II LLC") is the general partner of Ponoi II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of Ponoi II LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. Ponoi II LLC and the each of the Ponoi Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. The securities are directly held by The Column Group III, LP ("TCG III LP"). The Column Group III GP, LP ("TCG III GP") is the general partner of TCG III LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Ponoi Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. The securities are directly held by The Column Group III- A, LP ("TCG III-A LP"). TCG III GP is the general partner of TCG III-A LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG III GP are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG III GP and each of the Ponoi Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares. The securities are held directly by The David V. and Alena Z. Goeddel 2004 Trust. This warrant was fully exercisable as of the date of the Issuer's initial public offering. Due to SEC restrictions on the number of reporting owners, this is Form 1 of 2. /s/ James Evangelista, Attorney-in-Fact 2020-12-16