X0206 3 2018-07-18 0 0001434418 CONSTELLATION PHARMACEUTICALS INC CNST 0001615782 Topspin Fund L.P. 3 EXPRESSWAY PLAZA ROSLYN HEIGHTS NY 11577 0 0 1 0 0001745827 Topspin Biotech Fund II, L.P. 3 EXPRESSWAY PLAZA ROSLYN HEIGHTS NY 11577 0 0 1 0 0001685869 LG Management, LLC 3 EXPRESSWAY PLAZA ROSLYN HEIGHTS NY 11577 0 0 1 0 0001200183 GUTHART LEO 3 EXPRESSWAY PLAZA ROSLYN HEIGHTS, NY 11577 0 0 1 0 Series E Preferred Stock Common Stock 20762 D Series E-1 Preferred Stock Common Stock 15750 D Series F Preferred Stock Common Stock 408758 D Series E Preferred Stock Common Stock 726678 I By Funds Series E-1 Preferred Stock Common Stock 551306 I By Funds Series E Preferred Stock Common Stock 31143 I By MSSB C/F Leo A. Guthart Series E-1 Preferred Stock Common Stock 23627 I By MSSB C/F Leo A. Guthart The Series E Preferred Stock is convertible into Common Stock on a 8.56256-for-one basis into the number of shares of Common Stock shown in Column 3 at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering without payment of further consideration. The shares have no expiration date. The shares are directly held by Topspin Fund L.P. LG Management, LLC, the general partner of Topspin Fund L.P., may be deemed to have voting and dispositive power with respect to the shares. Leo A. Guthart, the managing member of LG Management, LLC, may also be deemed to have voting and dispositive power with respect to the shares. Each of LG Management, LLC and Leo A. Guthart disclaims beneficial ownership of the shares, except to the extent of their respective indirect pecuniary interests in such shares. The Series E-1 Preferred Stock is convertible into Common Stock on a 11.009-for-one basis into the number of shares of Common Stock shown in Column 3 at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering without payment of further consideration. The shares have no expiration date. The Series F Preferred Stock is convertible into Common Stock on a 11.009-for-one basis into the number of shares of Common Stock shown in Column 3 at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering without payment of further consideration. The shares have no expiration date. The shares are directly held by Topspin Biotech Fund L.P. LG Management, LLC, the general partner of Topspin Biotech Fund L.P., may be deemed to have voting and dispositive power with respect to the shares. Leo A. Guthart, the managing member of LG Management, LLC, may also be deemed to have voting and dispositive power with respect to the shares. Each of LG Management, LLC and Leo A. Guthart disclaims beneficial ownership of the shares, except to the extent of their respective indirect pecuniary interests in such shares. The shares are held directly by individual retirement accounts in the name of Leo A. Guthart and as a result Leo A Guthart may be deemed to be the beneficial owner of such shares. Leo A. Guthart disclaims beneficial ownership of such shares, except to the extent of his indirect pecuniary interest in such shares. /s/ Leo A. Guthart 2018-07-18