X0206 3 2018-07-18 0 0001434418 CONSTELLATION PHARMACEUTICALS INC CNST 0001746115 Audia James E C/O CONSTELLATION PHARMACEUTICALS, INC. 215 FIRST STREET, SUITE 200 CAMBRIDGE MA 02142 1 0 0 0 Common Stock 69034 D Stock Option (right to buy) 4.08 2022-03-06 Common Stock 11626 D Stock Option (right to buy) 5.62 2025-11-08 Common Stock 8515 D Stock Option (right to buy) 5.62 2025-11-08 Common Stock 16089 D Stock Option (right to buy) 7.60 2026-02-18 Common Stock 1277 D Stock Option (right to buy) 5.51 2027-02-16 Common Stock 2384 D Stock Option (right to buy) 5.51 2027-09-13 Common Stock 9083 D Stock Option (right to buy) 7.60 2028-03-07 Common Stock 9083 D This option was granted on March 7, 2012 and is fully vested. This option was granted on November 9, 2015 and is fully vested. This option was granted on November 9, 2015 and is fully vested. This option was granted on February 19, 2016 and is fully vested. This option was granted on February 17, 2017 and is fully vested. This option was granted on September 14, 2017 and is scheduled to vest as to 25% of the shares underlying the option on September 14, 2018, with the remainder vesting in equal quarterly installments through September 14, 2021. This option was granted on March 8, 2018 and is scheduled to vest as to 33% of the shares underlying the option on March 8, 2019, with the remainder vesting in equal quarterly installments through March 8, 2021. Exhibit Index: 24.1 Power of Attorney /s/ Emma Reeve, as attorney-in-fact for James E. Audia 2018-07-18