X0206 3 2018-07-18 0 0001434418 CONSTELLATION PHARMACEUTICALS INC CNST 0001745787 Raythatha Jigar C/O CONSTELLATION PHARMACEUTICALS, INC. 215 FIRST STREET, SUITE 200 CAMBRIDGE MA 02142 1 1 1 0 President and CEO Common Stock 14961 D Stock Option (right to buy) 5.51 2027-07-10 Common Stock 535925 D Stock Option (right to buy) 7.60 2028-03-05 Common Stock 141929 D Stock Option (right to buy) 8.04 2028-04-08 Common Stock 141929 D This option was granted on July 11, 2017, and has vested as to 25% of the shares underlying the options as of March 20, 2018 with the remainder of the shares vesting in equal quarterly installments through March 20, 2021. This option was granted on March 6, 2018. The shares underlying the option are scheduled to vest in equal quarterly installments through March 6, 2022. This option was granted on April 9, 2018. The shares underlying the option are scheduled to vest in equal quarterly installments through April 9, 2022. Exhibit Index: 24.1 Power of Attorney /s/ Emma Reeve, as attorney-in-fact for Jigar Raythatha 2018-07-18