X0306 4 2016-08-12 0 0000850261 Sorrento Therapeutics, Inc. SRNE 0001433982 ZELDIS JEROME B C/O SORRENTO THERAPEUTICS, INC. 9380 JUDICIAL DRIVE SAN DIEGO CA 92121 0 1 0 0 See Remarks Stock Options 6.52 2016-08-12 4 A 0 200000 0.00 A 2026-08-12 Common Stock 200000 200000 D 1/4 of the original number of shares subject to the option shall vest on August 12, 2017 and 1/48 of the original number of shares subject to the option shall vest following each one month period of service after August 12, 2017, subject to the Reporting Person's continued service to the Issuer through each such vesting date. Chief Medical Officer and President of Clinical Development /s/ Jerome Zeldis 2016-11-15