Equity (Details Narrative) - USD ($)					3 Months Ended
	Apr. 19, 2021	Feb. 08, 2021	Feb. 03, 2021	Jan. 11, 2021	Mar. 31, 2021	Mar. 31, 2020	Apr. 26, 2021	Dec. 31, 2020
Reverse stock split	One-for-fifty reverse stock split of its common stock
Common stock, par value	$ 0.0001				$ 0.0001	$ 0.0001
Common stock, shares issued					7,852,791			3,284,322
Common stock, shares outstanding					7,852,791			3,284,322
Number of warrants to purchase common stock					1,794,158
Warrants exercise price					$ 35.207
Conversion of series c convertible preferred stock to common shares, shares
Capital stock shares authorized					155,000,000
Capital stock par value					$ 0.0001
Common stock shares authorized					150,000,000	150,000,000
Employees and Directors [Member]
Number of restricted stock shares granted				4,200
Fair value of restricted stock granted				$ 42,207
Stock Options [Member]
Stock option granted				1,400
Stock option granted, exercise price				$ 10.05
Stock option vesting period				3 years
Dividend yield				0.00%
Volatility rate, minimum				129.12%
Volatility rate, maximum				136.78%
Risk free interest rate, minimum				0.59%
Risk free interest rate, maximum				0.76%
Fair value of stock options				$ 12,635
Series F And G Warrants [Member]
Number of issuance of public offering					1,225,412
Proceeds from sale of stock					$ 9,469,000
Series B Convertible Preferred Stock [Member]
Conversion of series b convertible preferred stock to common shares, shares					17,303
Series C Convertible Preferred Stock [Member]
Common stock, shares outstanding					1,718
Conversion of series c convertible preferred stock to common shares, shares					625
Preferred stock issued upon conversion					831
Securities Purchase Agreement [Member]
Number of issuance of public offering			89,445
Share price			$ 10.062
Proceeds from sale of stock			$ 900,000
Maximum [Member] | Stock Options [Member]
Expected term				6 years 6 months
Maximum [Member] | Series F And G Warrants [Member]
Warrants exercise price					$ 10.23
Minimum [Member] | Stock Options [Member]
Expected term				5 years 6 months
Minimum [Member] | Series F And G Warrants [Member]
Warrants exercise price					$ 7.425
Underwriter Warrants [Member] | Maximum [Member]
Number of warrants to purchase common stock		111,290
Series G Warrants [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares		145,161
Share price		$ 10.23
Warrants term		5 years
Common Stock [Member]
Conversion of series b convertible preferred stock to common shares, shares					207,528
Conversion of series c convertible preferred stock to common shares, shares					831	1,852
Common Stock [Member] | Series C Convertible Preferred Stock [Member]
Conversion of series c convertible preferred stock to common shares, shares					2,280
Preferred Stock Blank Check [Member]
Preferred stock shares authorized					5,000,000
Underwritten Public Offering [Member]
Common stock, par value		$ 0.0001
Number of issuance of public offering		1,935,484
Share price		$ 9.30
Over-Allotment Option [Member]
Number of issuance of public offering		290,322
Net proceeds from issuance of stock		$ 18,900,000
At The Market Offering [Member]
Sale of transaction shares					818,523
Sale of transaction					$ 5,659,000
Secretary of State of Delaware a Certificate of Amendment [Member]
Common stock, shares issued					117,800,000		7,900,000
Common stock, shares outstanding					117,800,000		7,900,000