Equity (Details Narrative) - USD ($)							12 Months Ended
		Jun. 05, 2020	Sep. 19, 2019	Apr. 12, 2019	Apr. 08, 2019	Mar. 27, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 14, 2020	Jul. 28, 2020	Jun. 02, 2020	Sep. 24, 2019	Apr. 04, 2019	Dec. 31, 2018
Reverse stock split						One-for-fifty reverse stock split of its common stock
Common stock, par value		$ 0.0001				$ 0.0001	$ 0.0001	$ 0.0001
Common stock, shares issued							49,264,830	3,916,134						38,400,000
Common stock, shares outstanding							49,264,830	3,916,134						38,400,000
Share price		$ 0.45
Number of warrants to purchase common stock							26,705,502			274,029
Warrants exercise price							$ 1.82			$ 0.495
Common units, shares		7,635,800
Common unit description		Each Unit being comprised of one share of the Company's common stock, par value $0.0001 per share, and one Series F warrant (a "Series F Warrant") to purchase one share of common stock.
Shares issued during the period new issue value								$ 6,335,000
Pre-funded warrants, shares								270,000
Outstanding pre-funded warrants are exercisable into shares of common stock
Proceeds from exercise of warrants							$ 16,395,000	$ 6,335,000
Capital stock shares authorized							155,000,000
Capital stock par value							$ 0.0001
Common stock shares authorized							150,000,000	150,000,000
Minimum [Member]
Warrants exercise price										187.50
Maximum [Member]
Warrants exercise price										$ 2.25
Stock Options [Member]
Stock option granted							1,379,856
Fair value of stock options							$ 509,000
Stock option vesting period							3 years
Stock Options [Member] | Minimum [Member]
Stock option granted, exercise price							$ 0.33
Stock Options [Member] | Maximum [Member]
Stock option granted, exercise price							$ 1.10
Restricted Stock [Member]
Stock granted							2,781,920	70,582
Fair value of restricted shares							$ 1,051,604	$ 668,000
Stock vesting period							3 years
Weighted average of the remaining contractual life of vested and exercisable options							4 years 7 months 28 days
Aggregate intrinsic value of exercisable options							$ 1
Weighted average fair value of options granted							$ 0.37
Restricted Stock Units (RSUs) [Member]
Stock granted							1,357,668	165,000
Stock vesting period							3 years
Fair value of restricted stock units							$ 658,981	$ 141,900
Employee and Non-employee Stock Options [Member]
Unvested stock-based compensation							$ 1,700,000
Unvested stock-based compensation weighted-average period for recognition							11 months 12 days
Common Stock [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares								3,039,161
Shares issued during the period new issue value	[1]
Over allotment shares		3,333,300
Shares outstanding							49,264,830	3,916,134						768,615
Warrant [Member]
Warrants outstanding							26,705,502
Preferred Stock Blank Check [Member]
Preferred stock shares authorized							5,000,000
Pre-Funded Units [Member]
Share price		$ 0.449
Common units, shares		14,586,400
Common unit description		Each Pre-Funded Unit being comprised of one pre-funded warrant (a "Pre-Funded Warrant") to purchase one share of common stock and one Series F Warrant.
Pre-Funded Warrants [Member]
Number of shares issued for exercise of warrants							14,586,400
Series B Convertible Preferred Stock [Member]
Shares of common stock issuable upon conversion			355,288										133,233
Preferred stock, shares outstanding			17,303										17,303
Series C Convertible Preferred Stock One [Member]
Shares of common stock issuable upon conversion			84,253										50,708
Preferred stock, shares outstanding			37,025										59,423
Underwriter Warrants [Member]
Number of warrants to purchase common stock							274,029
Warrants exercise price							$ 0.50
Series F Warrants [Member]
Common stock, par value		$ 0.0001
Share price		$ 0.45
Number of warrants to purchase common stock		1					22,688,900
Warrants exercise price							$ 0.50
Common units, shares		7,635,800
Over allotment shares		3,333,300
Proceeds from exercise of warrants		$ 10,700,000					$ 1,400,000
Conversion of converted shares							2,866,600
Series F Warrants [Member] | Pre-Funded Units [Member]
Warrants exercise price		$ 0.495
Warrants expiration date		Jun. 02, 2025
Preferred B Shares [Member]
Share price							$ 0.45
Preferred stock, shares outstanding							17,303	17,303
Additional shares of common stock									892,371		1,665,414
Shares outstanding									17,303		17,303
Preferred stock shares authorized							500,000	500,000
Preferred C Shares [Member]
Share price							$ 0.45
Preferred stock, shares outstanding							2,343	34,370
Additional shares of common stock									13,392		283,285
Shares outstanding									2,343		26,558
Preferred stock shares authorized							1,172,000	1,172,000
2019 Pre-Funded Units and Pre-Funded Warrants [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares								2,000,811
Number of warrants to purchase common stock								2,000,811
Shares issued during the period new issue value								$ 35,705
April 2019 Underwriter Warrants [Member]
Number of warrants to purchase common stock					34,955
Sale of stock, offering percentage					7.00%
Warrants exercise price					$ 6.25
Percentage for gross proceeds of offering					125.00%
Underwritten Public Offering [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares					486,957
Gross proceeds from offering					$ 2,000,000
Share price					$ 5.00
Over-Allotment Option [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares				12,393
Gross proceeds from offering				$ 47,000
Share price				$ 5.00
Over-Allotment Option [Member] | Series E Warrant [Member]
Number of warrants to purchase common stock												194,444
Warrants exercise price												$ 0.01
September 2019 Offering [Member]
Share price			$ 1.80
Common units, shares			539,000
Common unit description			Each 2019 Common Unit being comprised of one share of the Company's common stock and one Series E warrant (collectively, the "Series E Warrants") to purchase one share of common stock.
September 2019 Offering [Member] | Series E Warrant [Member]
Warrants exercise price			$ 1.80
September 2019 Offering [Member] | 2019 Pre-Fund Units [Member]
Share price			1.79
Warrants exercise price			$ 0.01
Common units, shares			2,238,777
Common unit description			Each 2019 Pre-Funded Unit being comprised of one pre-funded warrant (collectively, the "2019 Pre-Funded Warrants") to purchase one share of common stock and one Series E Warrant.
September 2019 Offering [Member] | Underwriter Warrants [Member]
Number of warrants to purchase common stock			194,444
Sale of stock, offering percentage			7.00%
Warrants exercise price			$ 0.01
Percentage for gross proceeds of offering			125.00%
Pre-fund warrants description			The September 2019 Underwriter Warrants are exercisable at any time and from time to time, in whole or in part, following the date of issuance and ending on September 19, 2024, at an exercise price of $2.25 per share (125% of the offering price to the public per 2019 Common Unit).
Proceeds from sale of stock			$ 5,000,000
At The Market Offering [Member] | Common Stock [Member]
Issuance of common shares, warrants, pre-funded warrants and exercise of pre-funded warrants, net of issuance costs, shares							12,917,448
Net proceeds from issuance of stock							$ 4,447,000
Secretary of State of Delaware a Certificate of Amendment [Member]
Common stock, shares issued						769,000
Common stock, shares outstanding						769,000

[1] Represents an amount less than $1