Equity (Details Narrative)					12 Months Ended
	Dec. 02, 2017 USD ($) $ / shares shares	Mar. 14, 2017 USD ($) $ / shares shares	Jul. 07, 2016 USD ($) $ / shares shares	Mar. 21, 2016 USD ($) $ / shares shares	Dec. 31, 2017 USD ($) $ / shares shares	Dec. 31, 2016 USD ($) $ / shares shares	Nov. 28, 2017 shares	Sep. 28, 2016 $ / shares shares	May 25, 2016 shares	May 24, 2016 shares	Sep. 09, 2015 shares	Dec. 16, 2013 shares	Mar. 28, 2011 shares
Common stock shares authorized					150,000,000	150,000,000
Common stock, par value | $ / shares					$ 0.0001	$ 0.0001
Common stock, shares issued					1,483,808	42,653
Common stock, shares outstanding					1,483,808	42,653
Proceeds from sale of stock | $				$ 1,400,000
Gross proceeds from offering, cost | $		$ 6,800,000			$ 15,000,000
Gross proceeds from offering, cost percentage		0.080
Shares issued during the period new issue value | $						$ 14,365,000
Conversion preferred to convertible securities | $
Fair value of embedded derivative | $					66,000
Basic loss per share to ordinary shares | $					(13,028,000)	$ (8,461,000)
Fair value of stock option | $					$ 526,000
Stock option vesting period					3 years
Weighted average of the remaining contractual life					8 years 8 months 12 days
Aggregate intrinsic value of the total exercisable warrants and options | $					$ 49,000
Weighted average fair value of warrants and options granted | $ / shares					$ 24.85	$ 108.85
Unvested stock-based compensation | $					$ 200,000
Intrinsic value of exercisable warrants and options during period | $ / shares					$ 0.13
Employee and Non-employee Stock Options
Weighted average of the remaining contractual life					9 months 29 days
Board Of Directors And Stockholders [Member] | 2013 Plan [Member]
Number of common stock awards reserve for future issuance					8,612							572
Stock option vested number of grant, shares					19,737			7,200		11,428	537
Chief Executive Officer [Member]
Stock option granted					118	9,392
Exercise price range lower limit | $ / shares					$ 24.85	$ 65.1
Exercise price range upper limit | $ / shares					$ 34.65	$ 437.5
Fair value of stock option | $					$ 3,000	$ 1,023,000
Stock option vesting period					3 years
Employees And Directors [Member]
Stock option granted					118	9,392
Exercise price range lower limit | $ / shares					$ 24.85	$ 65.1
Exercise price range upper limit | $ / shares					$ 34.65	$ 437.5
Fair value of stock option | $					$ 3,000	$ 1,023,000
Umbrella Plan [Member]
Number of common stock awards reserve for future issuance					276								572
Series A Warrants [Member]
Conversion of warrants to securities					50,620
Series B Warrants [Member]
Conversion of warrants to securities					122,269
Underwritten Public Offering [Member]
Number of common stock shares sold				3,384
Number of warrants to purchase common stock				1,706
Warrant terms				5 years
Warrant exercise price | $ / shares				$ 516.25
Proceeds from sale of stock | $				$ 1,700,000
Share price | $ / shares				$ 516.25
Three Years Of Vesting [Member]
Stock option granted					4,601
Two Years Of Vesting [Member]
Stock option granted					915
One Years Of Vesting [Member]
Stock option granted					2,399
Fully Vested [Member]
Stock option granted					810
Capital Units [Member]
Common stock shares authorized					155,000,000
Series B Convertible Preferred Stock [Member]
Shares issued during the period new issue					258,952
Preferred stock, shares outstanding					311,521
Convertible preferred stock shares issued upon conversion					284,446
Fair value of embedded derivative | $					$ 0
Series B Convertible Preferred Stock [Member] | Redemption Obligation [Member]
Gross proceeds from offering, cost percentage					0.125
Shares issued during the period new issue value | $					$ 1,000,000
Series B Convertible Preferred Stock [Member] | July 2016 Offering [Member]
Number of common stock shares sold			442,424
Number of warrants to purchase common stock			50,620
Warrant exercise price | $ / shares					$ 175.00
Share price | $ / shares			$ 33.00
Conversion stock shares converted			0.114		4,714
Convertible preferred stock conversion price per share | $ / shares			$ 288.75		$ 7.00
Cumulative dividend, percentage					15.00%
Gross proceeds from offering, cost | $			$ 14,600,000		$ 8,000,000
Option issued to purchase of shares percentage			0.035
Option issued exercise price percentage					1.25
Series B Convertible Preferred Stock [Member] | Private Placements [Member]
Convertible preferred stock conversion price per share | $ / shares					$ 7.00
Convertible preferred stock shares issued upon conversion					1,306,536		180,992
Common Stock [Member] | July 2016 Offering [Member]
Number of warrants to purchase common stock					1,106
Series C Convertible Preferred Stock [Member]
Number of common stock shares sold		1,069,822
Warrant exercise price | $ / shares		$ 6.40
Conversion stock shares converted		0.114			0.589
Convertible preferred stock conversion price per share | $ / shares		$ 56.00			$ 1.60
Series B Warrants [Member]
Number of common stock shares sold		122,269
Warrant exercise price | $ / shares		$ 70.00
Series C Warrants [Member]
Number of common stock shares sold		122,269
Warrant exercise price | $ / shares		$ 56.00
Gross proceeds from offering, cost percentage		0.030
Series D Convertible Preferred Stock [Member]
Convertible preferred stock shares issued upon conversion					206,105
Series D Convertible Preferred Stock [Member] | Private Placements [Member]
Proceeds from sale of stock | $	$ 750,000
Conversion stock shares converted	14,286				42,677
Convertible preferred stock conversion price per share | $ / shares	$ 7.00
Shares issued during the period new issue	750
Shares issued during the period new issue value | $	$ 1,000,000
Common shares outstanding percentage	0.20				0.1999
Redeemable Preferred Shares [Member]
Fair value of embedded derivative | $					$ 934,000
Series B Convertible Preferred Stock [Member]
Conversion stock shares converted					284,446
Conversion preferred to convertible securities | $					$ 1,404,424,000
Preferred Shares [Member]
Basic loss per share to ordinary shares | $					$ 3,900,000,000
Series D Convertible Preferred Stock One [Member]
Shares issued during the period new issue					8,295
Series C Convertible Preferred Stock One [Member]
Conversion stock shares converted					328,171
Conversion preferred to convertible securities | $					$ 37,506,000
Series B Convertible Preferred Stock Two[Member]
Conversion preferred to convertible securities | $					223,344,000
Series C Convertible Preferred Stock Three [Member]
Conversion preferred to convertible securities | $					84,753,000
Series D Convertible Preferred Stock Three [Member]
Conversion preferred to convertible securities | $					$ 107,143,000
Series D Convertible Preferred Stock Two [Member]
Number of warrants to purchase common stock					180,367
Conversion stock shares converted					180,367
Restricted Stock [Member]
Stock option granted					705,000
Restricted Stock [Member] | Chief Executive Officer [Member]
Stock option granted					84	3,710
Fair value of stock option | $					$ 3,000	$ 545,000
Restricted Stock [Member] | Employees And Directors [Member]
Stock option granted					84	3,710
Fair value of stock option | $					$ 3,000	$ 545,000
Restricted Stock [Member] | Three Years Of Vesting [Member]
Stock option granted						2,015
Minimum [Member]
Gross proceeds from offering, cost | $					25,000,000
Maximum [Member]
Number of warrants to purchase common stock				168
Warrant exercise price | $ / shares				$ 645.31
Maximum [Member] | Series B Convertible Preferred Stock [Member] | Redemption Obligation [Member]
Conversion preferred to convertible securities | $					274,000
Maximum [Member] | Series D Convertible Preferred Stock [Member] | Redemption Obligation [Member]
Shares issued during the period new issue value | $					$ 1,500,000
Maximum [Member] | Series B Convertible Preferred Stock [Member]
Convertible stock price, percentage					10.00%
Secretary of State of Delaware a Certificate of Amendment [Member]
Common stock shares authorized					150,000,000
Common stock, par value | $ / shares					$ 0.0001			$ 0.0001
Preferred stock, shares authorized					5,000,000
Common stock, shares issued								1,020,000
Common stock, shares outstanding								42,000
Secretary of State of Delaware a Certificate of Amendment [Member] | February 7, 2018 [Member]
Common stock, par value | $ / shares					$ 0.0001
Common stock, shares issued					51,900,000
Common stock, shares outstanding					1,500,000
Secretary of State of Delaware a Certificate of Amendment [Member] | Minimum [Member]
Common stock shares authorized									50,000,000
Secretary of State of Delaware a Certificate of Amendment [Member] | Maximum [Member]
Common stock shares authorized									150,000,000