<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-04-07</periodOfReport>

    <issuer>
        <issuerCik>0001430725</issuerCik>
        <issuerName>Global Ship Lease, Inc.</issuerName>
        <issuerTradingSymbol>GSL</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002121343</rptOwnerCik>
            <rptOwnerName>Giannopoulos Georgios</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>true</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>9 IRODOU ATTIKOU STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>KIFISIA, ATHENS</rptOwnerCity>
            <rptOwnerNonUSStateTerritory></rptOwnerNonUSStateTerritory>
            <rptOwnerCountry>J3</rptOwnerCountry>
            <rptOwnerZipCode>14561</rptOwnerZipCode>
            <rptOwnerStateDescription>GREECE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Compliance Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Shares, par value of $0.01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2026-04-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7692</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>38.511</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A Common Shares, par value of $0.01 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>142308</value>
                    <footnoteId id="F3"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Class A Common Shares of Global Ship Lease, Inc. (the &quot;Issuer&quot;) granted to the reporting person pursuant to the Issuer's 2019 Omnibus Incentive Plan, as amended and restated (the &quot;Plan&quot;).</footnote>
        <footnote id="F2">The price reported represents the weighted average price of Class A Common Shares of the Issuer sold in multiple transactions at prices ranging from $38.44 to $38.66 per share. The reporting person will provide to the Issuer, or the U.S. Securities and Exchange Commission staff, upon request, information regarding the number of shares sold at each price within the range.</footnote>
        <footnote id="F3">Unvested awards of Class A Common Shares of the Issuer granted to the reporting person pursuant to the Plan, consisting of (i) 42,308 shares which vest quarterly, pro rata, commencing from the quarter ended June 30, 2026, conditioned on the reporting person's continued service, (ii) 50,000 shares, of which approximately 1/3 are earned upon the Company's achievement of a specified annualized return on equity that is measured as of December 31 of 2026, 2027 and 2028, respectively, after which, such earned shares are notionally divided into a number of quarterly installments within the 3.25 year period beginning October 1, 2025 (the &quot;Term&quot;) and are eligible to vest on this basis, and (iii) 50,000 shares which vest at December 31, 2028 based on the Company's achievement of a specified return on equity over the full Term.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ George Giannopoulos</signatureName>
        <signatureDate>2026-04-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
