X0306 4 2016-09-29 0 0001429560 TREVENA INC TRVN 0001280044 GOWEN MAXINE C/O TREVENA, INC. 1018 WEST 8TH AVENUE, SUITE A KING OF PRUSSIA PA 19406 1 1 0 0 President & CEO Common Stock 2016-09-29 5 G 0 E 130000 0.00 D 163109 D Common Stock 2016-09-29 5 G 0 E 130000 0.00 A 134000 I By Spouse Common Stock 2016-10-17 5 G 0 E 135025 0.00 D 28084 D Common Stock 2016-10-17 5 G 0 E 135025 0.00 A 135025 I By Trust Common Stock 2016-10-17 5 G 0 E 10000 0.00 D 18084 D Common Stock 2016-10-17 5 G 0 E 10000 0.00 A 144000 I By Spouse This transaction involved a gift of securities by the reporting person to her spouse. These shares are held by the reporting person's spouse. The reporting person disclaims beneficial ownership of the shares held by her spouse, and this report should not be deemed an admission that the reporting person is the beneficial owner of her spouse's shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. This transaction involved a gift of securities by the reporting person to the Brian MacDonald Irrevocable Trust. These shares are held by the Brian MacDonald Irrevocable Trust. The reporting person's spouse is the beneficiary and the Trustee of the Brian MacDonald Irrevocable Trust. The reporting person disclaims beneficial ownership of the shares held by the Brian MacDonald Irrevocable Trust, and this report should not be deemed an admission that the reporting person is the beneficial owner of her children's shares for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. /s/John Limongelli, Attorney-in-Fact 2016-10-19