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                          January 16, 2024

       Barry Shin
       Chief Financial Officer
       Trevena, Inc.
       955 Chesterbrook Boulevard, Suite 110
       Chesterbrook, PA 19087

                                                        Re: Trevena, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed January 10,
2024
                                                            File No. 333-276458

       Dear Barry Shin:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tim
Buchmiller at 202-551-3635 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Scott R. Jones, Esq.