License Revenue and Reimbursable Expenses (Details) - USD ($) $ in Millions	1 Months Ended			3 Months Ended
	Mar. 31, 2021	Jul. 31, 2020	Jul. 31, 2017	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received			$ 10.0
License agreements, first commercial sale anniversary			10 years
Reimbursable expenses				$ 9.1	$ 14.3
Receivable of reimbursable development expenses				14.1		$ 11.8
Collaborative Arrangement | Teijin Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received	$ 10.0		$ 10.0
Additional payments to be made upon achievement of certain milestones			$ 40.0
Berlin-Chemie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received		$ 30.0
Reimbursement of cost				$ 114.6
Collaborative Agreement Royalty Period		10 years
Collaborative agreement, termination, period of no manufacture or commercialization activity				24 months
Collaborative agreement, termination, number of days of prior notice given by counterparty				180 days
Upfront payment received				$ 30.0
License				27.4
Inventory				2.6
Berlin-Chemie | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Development and regulatory milestone payments receivable				20.0
Sales milestone payments receivable				$ 300.0