Product Revenue Reserves and Allowances (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Product Revenue Allowance and Reserves
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	$ 26,889	$ 19,107
Provision related to sales in the current year	34,659	30,182
Adjustments related to prior period sales	239	(2,873)
Credits and payments made	(32,967)	(24,191)
Ending balance	28,820	22,225
Chargebacks, Discounts, and Fees
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	2,061	1,891
Provision related to sales in the current year	4,453	4,383
Adjustments related to prior period sales	0	(90)
Credits and payments made	(4,690)	(5,080)
Ending balance	1,824	1,104
Government and other rebates
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	24,604	14,644
Provision related to sales in the current year	30,087	25,681
Adjustments related to prior period sales	239	(534)
Credits and payments made	(28,168)	(18,984)
Ending balance	26,762	20,807
Returns
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	224	2,572
Provision related to sales in the current year	119	118
Adjustments related to prior period sales	0	(2,249)
Credits and payments made	(109)	(127)
Ending balance	$ 234	$ 314