License Revenue and Reimbursable Expenses (Details) - USD ($) $ in Thousands	1 Months Ended		3 Months Ended		9 Months Ended
	Mar. 31, 2021	Jul. 31, 2017	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received		$ 10,000
License agreements, first commercial sale anniversary		10 years
License revenue			$ 56,810	$ 77,826	$ 164,867	$ 175,862
Reimbursable expenses			14,600	15,400	47,400	15,400
Receivable of reimbursable development expenses			19,200		19,200
License revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License revenue			$ 0	$ 27,414	11,000	$ 27,414
Collaborative Arrangement | Teijin Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received		$ 10,000
Additional payments to be made upon achievement of certain milestones	$ 10,000	$ 40,000
Berlin-Chemie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Reimbursement of cost					$ 114,600
Collaborative agreement, termination, period of no manufacture or commercialization activity					24 months
Collaborative agreement, termination, number of days of prior notice given by counterparty					180 days
Upfront payment received					$ 30,000
License					27,400
Inventory					2,600
Berlin-Chemie | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Development and regulatory milestone payments receivable					20,000
Sales milestone payments receivable					$ 300,000