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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
CASH FLOWS USED IN OPERATING ACTIVITIES:    
Net loss $ (81,534) $ (78,234)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 945 1,219
Amortization of discount on marketable securities, net 132 (132)
Amortization of debt discount and debt issuance costs 8,725 7,628
Impairment loss on operating lease right of use assets 0 339
Stock-based compensation 13,299 11,863
(Gain)/Loss on property and equipment disposals 0 201
Changes in operating assets and liabilities:    
Inventory (583) 1,053
Accounts receivable, net 5,390 (6,891)
Prepaid expenses 4,210 5,656
Other current assets (992) 329
Operating lease right of use assets 1,027 1,010
Other long-term assets 0 58
Accounts payable 5,688 1,815
Accrued expenses and other current liabilities (1,274) 1,556
Lease liability, operating leases (1,102) (1,140)
Other non-current liabilities 0 (48)
Net cash used in operating activities (46,069) (53,718)
CASH FLOWS PROVIDED BY INVESTING ACTIVITIES:    
Purchases of marketable securities (39,907) (33,595)
Sales and maturities of marketable securities 61,400 90,000
Net cash provided by investing activities 21,493 56,405
CASH FLOWS PROVIDED BY FINANCING ACTIVITIES:    
Proceeds from exercise of stock options and warrant exercises 0 3,869
Proceeds from issuance of term loan, net 9,939 0
Proceeds from issuance of shares under employee stock purchase plan 990 1,027
Net cash provided by financing activities 10,929 4,896
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH (13,647) 7,583
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT BEGINNING OF YEAR 70,453 59,881
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT END OF PERIOD 56,806 67,464
SUPPLEMENTAL DISCLOSURES:    
Cash paid for interest 4,818 4,575
Cash paid for amounts included in the measurement of operating lease liabilities 1,175 685
Right of use assets obtained in exchange for operating lease liability $ 1,110 $ 8,289