Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
OPERATING EXPENSES:
Cost of sales - product	$ 15,287	$ 7,627	$ 932
Cost of sales - intangible amortization	798	799	400
Research and development	116,757	99,911	83,076
Selling, general and administrative	152,704	184,164	186,677
Other operating expense	0	10,801	0
Loss from operations	(112,229)	(204,063)	(248,973)
OTHER (EXPENSE) INCOME:
Other income (expense), net	242	59	(192)
Interest income	3,929	5,622	3,226
Interest expense	(24,935)	(22,955)	(8,298)
NET LOSS	(132,993)	(221,337)	(254,237)
OTHER COMPREHENSIVE LOSS:
Unrealized gain (loss) from available-for-sale securities	758	(441)	(385)
COMPREHENSIVE LOSS	(132,235)	(221,778)	(254,622)
LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS—BASIC	(132,993)	(221,337)	(254,237)
LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS—DILUTED	$ (132,993)	$ (221,337)	$ (254,237)
LOSS PER SHARE:
Basic and diluted (in dollars per share)	$ (2.89)	$ (4.88)	$ (5.80)
WEIGHTED AVERAGE SHARES:
Basic and diluted (in shares)	46,026,217	45,356,263	43,804,660
Product
REVENUES:
Revenue	$ 173,317	$ 99,239	$ 12,112
License
REVENUES:
Revenue	$ 0	$ 0	$ 10,000