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Stock-Based Compensation - Summary of Stock Options (Details) - Options to purchase common stock
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2019
USD ($)
$ / shares
shares
Shares  
Options outstanding at beginning of period (in shares) | shares 5,463
Granted (in shares) | shares 808
Exercised (in shares) | shares (185)
Canceled (in shares) | shares (176)
Expired (in shares) | shares (136)
Options outstanding at end of period (in shares) | shares 5,774
Options exercisable at end of period (in shares) | shares 3,226
Weighted- Average Exercise Price (in dollars per share)  
Options outstanding at the beginning of the period (in dollars per share) | $ / shares $ 36.88
Granted (in dollars per share) | $ / shares 18.96
Exercised (in dollars per share) | $ / shares 8.18
Canceled (in dollars per share) | $ / shares 38.81
Expired (in dollars per share) | $ / shares 48.48
Options outstanding at the end of the period (in dollars per share) | $ / shares 34.96
Options exercisable at the end of the period (in dollars per share) | $ / shares $ 38.13
Weighted- Average Contractual Life (in years)  
Options outstanding at the end of period 7 years 142 days
Options exercisable at the end of period 6 years 62 days
Aggregate Intrinsic Value  
Options outstanding at the end of the period (in dollars) | $ $ 5,775
Options exercisable at the end of the period (in dollars) | $ $ 4,791