Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
CASH FLOWS USED IN OPERATING ACTIVITIES:
Net loss	$ (221,337)	$ (254,237)	$ (182,804)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	2,867	1,951	586
Amortization of premium (accretion of discount) on marketable securities, net	(390)	(264)	791
Stock-based compensation expense	28,701	35,003	26,058
Non-cash interest	13,800	4,816	0
Changes in operating assets and liabilities:
Inventory	(1,844)	(4,366)	0
Trade receivables, net	(12,317)	(4,441)	0
Prepaid expenses	(8,667)	(3,689)	(342)
Other current assets	989	(1,362)	4,996
Other long-term assets	255	(248)	(291)
Accounts payable	311	(2,213)	(100)
Accrued expenses and other current liabilities	(7,000)	22,563	11,349
Other non-current liabilities	(94)	(190)	0
Net cash used in operating activities	(204,726)	(206,677)	(139,757)
CASH FLOWS (USED IN) PROVIDED BY INVESTING ACTIVITIES:
Purchases of property and equipment	(185)	(2,341)	(2,936)
Payment of milestone related to intangible asset	0	(8,712)	0
Purchases of marketable securities	(499)	(429,296)	(260,547)
Sales and maturities of marketable securities	135,000	191,363	499,603
Net cash (used in) provided by investing activities	134,316	(248,986)	236,120
CASH FLOWS PROVIDED BY FINANCING ACTIVITIES:
Proceeds from exercise of stock options	9,106	17,478	2,573
Proceeds from issuance of convertible notes	0	305,000	0
Deferred financing costs	0	(9,360)	0
Proceeds from employee stock purchase plan	2,566	2,550	0
Net cash provided by financing activities	11,672	315,668	2,573
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH	(58,738)	(139,995)	98,936
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT BEGINNING OF YEAR	118,619	258,614	159,678
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT END OF YEAR	59,881	118,619	258,614
SUPPLEMENTAL DISCLOSURES:
Cash paid for interest	9,582	0	0
Property and equipment purchases in accrued expense	$ 309	$ 352	$ 675

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

+ Details

Name:	us-gaap_ShareBasedCompensation
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

- References

No definition available.

+ Details

Name:	us-gaap_SupplementalCashFlowElementsAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration