Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
OPERATING EXPENSES:
Cost of sales - product	$ 7,627	$ 932	$ 0
Cost of sales - intangible amortization	799	400	0
Research and development	99,911	83,076	107,406
Selling, general and administrative	184,164	186,677	77,542
Other operating expense	10,801	0	0
Loss from operations	(204,063)	(248,973)	(184,948)
OTHER (EXPENSE) INCOME:
Other income (expense), net	59	(192)	(293)
Interest income	5,622	3,226	2,437
Interest expense	(22,955)	(8,298)	0
NET LOSS	(221,337)	(254,237)	(182,804)
OTHER COMPREHENSIVE LOSS, NET OF TAX:
Unrealized gain (loss) from available-for-sale securities	(441)	(385)	66
COMPREHENSIVE LOSS	(221,778)	(254,622)	(182,738)
LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS—BASIC AND DILUTED (Note 12)	$ (221,337)	$ (254,237)	$ (182,804)
LOSS PER SHARE:
Basic and diluted (in dollars per share)	$ (4.88)	$ (5.80)	$ (4.24)
WEIGHTED AVERAGE SHARES:
Basic and diluted (in shares)	45,356,263	43,804,660	43,067,952
Product
REVENUES:
Revenue	$ 99,239	$ 12,112	$ 0
License
REVENUES:
Revenue	$ 0	$ 10,000	$ 0