XML 64 R52.htm IDEA: XBRL DOCUMENT v3.10.0.1
License Agreements (Details)
€ in Millions
1 Months Ended 3 Months Ended 4 Months Ended 7 Months Ended 9 Months Ended 12 Months Ended 106 Months Ended 147 Months Ended 154 Months Ended
Sep. 30, 2018
USD ($)
Feb. 27, 2018
Oct. 31, 2018
USD ($)
Dec. 31, 2017
USD ($)
Oct. 31, 2017
USD ($)
Apr. 30, 2017
USD ($)
Apr. 30, 2017
EUR (€)
Mar. 31, 2015
USD ($)
Jun. 30, 2009
Sep. 30, 2005
USD ($)
Sep. 30, 2005
EUR (€)
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Apr. 28, 2017
USD ($)
Dec. 31, 2006
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2018
EUR (€)
Sep. 30, 2017
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
USD ($)
Mar. 31, 2018
USD ($)
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Jul. 31, 2017
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Milestone payments that triggered intangible asset recognition                               $ 0   $ 8,712,000            
Research and development                       $ 26,804,000 $ 20,997,000 $ 1,600,000   75,979,000   $ 60,176,000            
Eisai | License Agreement                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Period after the date of the first commercial sale of the product for license expiration               10 years                                
Initial license fee paid                             $ 500,000         $ 400,000        
Eisai | License Agreement | Maximum                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Payments to be made upon achievement of certain clinical and regulatory milestones               $ 22,300,000.0                                
Collaborative Arrangement | 3M Company                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Initial term   5 years                                            
Renewal term   3 years             1 year                              
Termination period   24 months             90 days                              
Nonrefundable, non-creditable payment                                         $ 24,000,000      
Collaborative Arrangement | Ipsen                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Nonrefundable, non-creditable payment                                             $ 13,000,000  
Milestone payments that triggered intangible asset recognition           $ 8,700,000 € 8.0                 8,700,000 € 8.0              
Royalty rate (as a percent)                   5.00% 5.00%                          
Royalty expense                       $ 1,400,000       3,200,000                
Collaborative Arrangement | Ipsen | Minimum                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Period after the date of the first commercial sale of the product for license expiration                   10 years 10 years                          
Collaborative Arrangement | Ipsen | Maximum                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Additional payments to be made upon achievement of certain development and commercialization milestones                   $ 28,000,000 € 24.0                          
Collaborative Arrangement | Ipsen | License Agreement                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
License agreement, obligation to pay                               $ 5,000,000                
Collaborative Arrangement | Eisai                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Nonrefundable, non-creditable payment                                           $ 1,000,000    
Collaborative Arrangement | Duke                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Termination period       60 days                                        
Nonrefundable, non-creditable payment $ 500,000                                              
Additional payments to be made upon achievement of certain development and commercialization milestones       $ 3,800,000                                        
Research and development                                     $ 1,300,000          
Collaborative Arrangement | Teijin Agreement                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Aggregate amount if regulatory and sales milestones are achieved                                               $ 40,000,000.0
Collaborative Arrangement | Teijin Agreement | Maximum                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
License agreement, upfront payment received         $ 10,000,000                                      
Scenario, Forecast | Collaborative Arrangement | 3M Company                                                
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                                
Collaborative Arrangement Funding to Purchase Capital Equipment     $ 9,600,000