Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
OPERATING EXPENSES:
Cost of sales - intangible amortization	$ 200	$ 200	$ 599	$ 200
Research and development	26,804	20,997	75,979	60,176
Selling, general and administrative	43,661	47,723	140,266	135,943
Other operating expenses	0	0	10,801	0
Loss from operations	(45,219)	(55,704)	(167,714)	(182,228)
OTHER (EXPENSE) INCOME:
Other income (expense)	17	(195)	83	(212)
Interest expense	(5,793)	(2,763)	(17,041)	(2,763)
Interest income	1,193	819	4,433	1,983
NET LOSS	(49,802)	(57,843)	(180,239)	(183,220)
OTHER COMPREHENSIVE LOSS:
Unrealized gain (loss) from available-for-sale debt securities	442	(1)	(534)	(70)
COMPREHENSIVE LOSS	(49,360)	(57,844)	(180,773)	(183,290)
LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS - BASIC AND DILUTED	$ (49,802)	$ (57,843)	$ (180,239)	$ (183,220)
LOSS PER SHARE:
Basic and diluted (in dollars per share)	$ (1.09)	$ (1.31)	$ (3.98)	$ (4.21)
WEIGHTED AVERAGE SHARES:
Basic and diluted (in shares)	45,498,909	43,999,451	45,291,176	43,535,874
Product
REVENUES:
Product revenue, net	$ 27,639	$ 3,469	$ 64,815	$ 4,449
OPERATING EXPENSES:
Cost of sales - product	2,193	253	4,884	358
License
REVENUES:
Product revenue, net	$ 0	$ 10,000	$ 0	$ 10,000