Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Payables and Accruals [Abstract]
Commercial costs and product revenue reserves	$ 13,567	$ 14,300
Research and development costs	11,212	8,406
Payroll and employee benefits	11,619	16,934
Interest	763	3,482
Restructuring costs	628	0
Professional fees	3,875	6,295
Other current liabilities	95	95
Total accrued expenses and other current liabilities	$ 41,759	$ 49,512