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License Agreements (Details)
€ in Millions
1 Months Ended 3 Months Ended 4 Months Ended 6 Months Ended 7 Months Ended 12 Months Ended 106 Months Ended 154 Months Ended
Feb. 27, 2018
Dec. 31, 2017
USD ($)
Oct. 31, 2017
USD ($)
Apr. 30, 2017
USD ($)
Apr. 30, 2017
EUR (€)
Mar. 31, 2015
USD ($)
Jun. 30, 2009
Sep. 30, 2005
USD ($)
Sep. 30, 2005
EUR (€)
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Apr. 28, 2017
USD ($)
Jun. 30, 2018
USD ($)
Jun. 30, 2018
EUR (€)
Jun. 30, 2017
USD ($)
Dec. 31, 2006
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
USD ($)
Mar. 31, 2018
USD ($)
Jun. 30, 2018
USD ($)
Jul. 31, 2017
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Milestone payments that triggered intangible asset recognition                         $ 0   $ 8,712,000            
Research and development                   $ 26,324,000 $ 19,652,000 $ 1,600,000 49,175,000   $ 39,179,000            
Eisai | License Agreement                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Period after the date of the first commercial sale of the product for license expiration           10 years                              
Initial license fee paid                               $ 500,000   $ 400,000      
Eisai | License Agreement | Maximum                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Payments to be made upon achievement of certain clinical and regulatory milestones           $ 22,300,000.0                              
Collaborative Arrangement | 3M Company                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Initial term 5 years                                        
Renewal term 3 years           1 year                            
Termination period 24 months           90 days                            
Nonrefundable, non-creditable payment                                     $ 22,300,000    
Collaborative Arrangement | Ipsen                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Nonrefundable, non-creditable payment                                       $ 13,000,000  
Milestone payments that triggered intangible asset recognition       $ 8,700,000 € 8.0               8,700,000 € 8.0              
Royalty rate (as a percent)               5.00% 5.00%                        
Royalty expense                   $ 1,100,000     $ 1,800,000                
Collaborative Arrangement | Ipsen | Minimum                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Period after the date of the first commercial sale of the product for license expiration               10 years 10 years                        
Collaborative Arrangement | Ipsen | Maximum                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Additional payments to be made upon achievement of certain development and commercialization milestones               $ 28,000,000 € 24.0                        
Collaborative Arrangement | Duke                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Termination period   60 days                                      
Additional payments to be made upon achievement of certain development and commercialization milestones   $ 3,800,000                                      
Research and development                                 $ 1,300,000        
Collaborative Arrangement | Teijin Agreement                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
Aggregate amount if regulatory and sales milestones are achieved                                         $ 40,000,000.0
Collaborative Arrangement | Teijin Agreement | Maximum                                          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                          
License agreement, upfront payment received     $ 10,000,000