XML 61 R49.htm IDEA: XBRL DOCUMENT v3.8.0.1
License Agreements (Details)
€ in Millions
1 Months Ended 3 Months Ended 4 Months Ended 7 Months Ended 12 Months Ended 106 Months Ended 151 Months Ended
Feb. 27, 2018
Dec. 31, 2017
USD ($)
Oct. 31, 2017
USD ($)
Apr. 30, 2017
USD ($)
Apr. 30, 2017
EUR (€)
Mar. 31, 2015
USD ($)
Jun. 30, 2009
Sep. 30, 2005
USD ($)
Sep. 30, 2005
EUR (€)
Mar. 31, 2018
USD ($)
Mar. 31, 2018
EUR (€)
Mar. 31, 2017
USD ($)
Apr. 28, 2017
USD ($)
Dec. 31, 2006
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2015
USD ($)
Mar. 31, 2018
USD ($)
Mar. 31, 2018
USD ($)
Jul. 31, 2017
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Research and development                   $ 22,851,000   $ 19,527,000 $ 1,600,000            
Eisai | License Agreement                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Period after the date of the first commercial sale of the product for license expiration           10 years                          
Initial license fee paid                           $ 500,000   $ 400,000      
Eisai | License Agreement | Maximum                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Payments to be made upon achievement of certain clinical and regulatory milestones           $ 22,300,000.0                          
Collaborative Arrangement | 3M Company                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Initial term 5 years                                    
Renewal term 3 years           1 year                        
Termination period 24 months           90 days                        
Nonrefundable, non-creditable payment                                 $ 21,500,000    
Collaborative Arrangement | Ipsen                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Nonrefundable, non-creditable payment                                   $ 13,000,000  
Milestone payments that triggered intangible asset recognition       $ 8,700,000 € 8.0         8,700,000 € 8.0                
Royalty rate (as a percent)               5.00% 5.00%                    
Royalty expense                   $ 700,000                  
Collaborative Arrangement | Ipsen | Minimum                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Period after the date of the first commercial sale of the product for license expiration               10 years 10 years                    
Collaborative Arrangement | Ipsen | Maximum                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Additional payments to be made upon achievement of certain development and commercialization milestones               $ 29,600,000 € 24.0                    
Collaborative Arrangement | Duke                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Termination period   60 days                                  
Additional payments to be made upon achievement of certain development and commercialization milestones   $ 3,800,000                                  
Research and development                             $ 1,300,000        
Collaborative Arrangement | Teijin Agreement                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
Aggregate amount if regulatory and sales milestones are achieved                                     $ 40,000,000.0
Collaborative Arrangement | Teijin Agreement | Maximum                                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                                      
License agreement, upfront payment received     $ 10,000,000