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Employee Stock Benefit Plans - Narrative (Details) - USD ($)
1 Months Ended 2 Months Ended 6 Months Ended 12 Months Ended
Apr. 30, 2016
Sep. 30, 2015
May 08, 2016
Nov. 27, 2017
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Inducement stock options issued (in shares)     341,450 490,000      
Grant date fair value (in dollars per share)         $ 22.74 $ 19.79 $ 30.52
Award expiration period         10 years    
Minimum              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Grant date fair value (in dollars per share)     $ 30.25 $ 27.80      
Maximum              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Grant date fair value (in dollars per share)     $ 33.49 $ 42.97      
Stock option / 2011 Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares of common stock authorized for issuance (in shares)         9,860,000    
Number of shares available for grant (in shares)         2,688,000    
Employee stock purchase plan / 2016              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares of common stock authorized for issuance (in shares)         1,290,594    
Number of shares available for grant (in shares)         1,214,314    
Exercise price of options as percentage of fair value of common stock on the date of grant         85.00%    
Award offering period         6 months    
Award maximum compensation         25.00%    
Deferred compensation liability         $ 1,300,000    
Options to purchase common stock              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Options outstanding (in shares)         5,648,000 6,374,000  
Inducement stock options issued (in shares)         2,094,000    
Aggregate intrinsic value of options vested during the period         $ 33,100,000 $ 3,700,000  
Options to purchase common stock | Stock option / 2011 Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares of common stock authorized for issuance (in shares)         8,976,000    
Exercise price of options as percentage of fair value of common stock on the date of grant         100.00%    
Exercise price of options as percentage of fair value of common stock on the date of grant in case of options granted to stockholder owning in excess of 10% of Company's common stock         110.00%    
Percentage of ownership required in entity's common stock for specified exercise price         10.00%    
Exercise period         10 years    
Exercise period in case of stock options granted to stockholder owning in excess of 10% of the company's common stock         5 years    
Award vesting period         4 years    
Options to purchase common stock | Stock option / 2003 Plan              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Number of shares of common stock authorized for issuance (in shares)         884,000    
Exercise price of options as percentage of fair value of common stock on the date of grant         100.00%    
Exercise price of options as percentage of fair value of common stock on the date of grant in case of options granted to stockholder owning in excess of 10% of Company's common stock         110.00%    
Percentage of ownership required in entity's common stock for specified exercise price         10.00%    
Exercise period         10 years    
Exercise period in case of stock options granted to stockholder owning in excess of 10% of the company's common stock         5 years    
Award vesting period         4 years    
Employee Stock Option              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Total unrecognized compensation expense         $ 51,100,000    
Weighted average period over which unrecognized compensation is expected to be recognized         3 years    
Restricted Stock Units (RSUs)              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period         4 years    
Grant date fair value (in dollars per share) $ 33.03       $ 38.62    
Total unrecognized compensation expense         $ 4,500,000    
Weighted average period over which unrecognized compensation is expected to be recognized         3 years    
Granted (in shares) 58,500       137,000    
Performance units (PSUs)              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period   1 year          
Grant date fair value (in dollars per share)         $ 0 $ 0 $ 49.59
Award expiration period   3 years          
Total unrecognized compensation expense         $ 0    
Granted (in shares)         0    
Performance units awarded to employee (in shares)   25,000          
Period used to calculate average closing stock price on grant date   45 days          
Tranche one, 25% on year anniversary of employee hire date              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting rights, percentage         25.00%    
Tranche one, 75% the following three years              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]              
Award vesting period         3 years    
Award vesting rights, percentage         75.00%