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Employee Stock Benefit Plans (Details 2) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 2 Months Ended 12 Months Ended
Sep. 30, 2015
May 08, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Summary of stock-based compensation expense          
Granted (in shares)   341,450      
Award expiration period   10 years      
Share-based compensation expense included in operating expenses     $ 26,058 $ 14,734 $ 7,070
Grant date fair value (in dollars per share)     $ 19.79 $ 30.52 $ 8.26
Research and development          
Summary of stock-based compensation expense          
Share-based compensation expense included in operating expenses     $ 11,190 $ 7,864 $ 1,953
General and administrative          
Summary of stock-based compensation expense          
Share-based compensation expense included in operating expenses     $ 14,868 $ 6,870 $ 5,117
Performance units          
Summary of stock-based compensation expense          
Performance units granted (in shares) 25,000        
Award expiration period 3 years        
Period used to calculate average closing stock price on grant date (in days) 45 days        
Award vesting period 1 year        
Weighted average grant date fair value of awards (in dollars per share)     $ 0 $ 49.59  
Total unrecognized compensation expense     $ 400    
Weighted average period over which unrecognized compensation is expected to be recognized     2 years