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License Agreements (Details)
€ in Millions
1 Months Ended 7 Months Ended 12 Months Ended
Jun. 30, 2016
USD ($)
Mar. 30, 2015
USD ($)
Dec. 31, 2006
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2016
EUR (€)
Dec. 31, 2005
USD ($)
Eisai | License Agreement            
Research Agreements            
Period after the date of the first commercial sale of the product for license expiration       10 years 10 years  
Initial license fee paid   $ 400,000 $ 500,000      
Additional payments to be made upon achievement of certain clinical and regulatory milestones $ 22,300,000.0          
Clinical Trial Services Agreement | Ipsen            
Research Agreements            
Nonrefundable, non-creditable payment           $ 4,300,000
Royalty rate (as a percent)       5.00% 5.00%  
Clinical Trial Services Agreement | Ipsen | Minimum            
Research Agreements            
Period after the date of the first commercial sale of the product for license expiration       10 years 10 years  
Clinical Trial Services Agreement | Ipsen | Maximum            
Research Agreements            
Additional payments to be made upon achievement of certain development and commercialization milestones       $ 33,600,000 € 32.0  
Clinical Trial Services Agreement | Ipsen | Sublicense Agreement            
Research Agreements            
Period after the date of the first commercial sale of the product for license expiration       10 years 10 years  
Agreement expiration period, period after date of first commercial sale of product       10 years 10 years