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License Agreements (Details)
€ in Millions
1 Months Ended 12 Months Ended
Mar. 09, 2015
USD ($)
Jun. 30, 2006
USD ($)
Dec. 31, 2015
EUR (€)
Dec. 31, 2015
USD ($)
Eisai | License Agreement        
License Agreements        
Period after the date of the first commercial sale of the product for license expiration     10 years 10 years
Initial license fee paid   $ 500,000    
Eisai | License Agreement | Minimum        
License Agreements        
Payments to be made upon achievement of certain clinical and regulatory milestones       $ 1,000,000
Eisai | License Agreement | Maximum        
License Agreements        
Payments to be made upon achievement of certain clinical and regulatory milestones       20,000,000
Eisai | Eisai Amendment | Research and development        
License Agreements        
Initial license fee paid $ 400,000      
Clinical Trial Services Agreement | Ipsen        
License Agreements        
Nonrefundable, non-creditable payment       $ 250,000
Royalty rate (as a percent)     5.00% 5.00%
Clinical Trial Services Agreement | Ipsen | Minimum        
License Agreements        
Additional payments to be made upon achievement of certain development and commercialization milestones     € 10.0 $ 10,900,000
Period after the date of the first commercial sale of the product for license expiration     10 years 10 years
Clinical Trial Services Agreement | Ipsen | Maximum        
License Agreements        
Additional payments to be made upon achievement of certain development and commercialization milestones     € 36.0 $ 39,100,000
Clinical Trial Services Agreement | Ipsen | Sublicense Agreement | Maximum        
License Agreements        
Period after the date of the first commercial sale of the product for license expiration     10 years 10 years