Net Loss Per Share (Tables)

12 Months Ended

Dec. 31, 2015

Net Loss Per Share

Schedule of basic and diluted net loss per share

        Basic and diluted net loss per share is calculated as follows (in thousands, except share and per share amounts):

	Year Ended December 31,
	2015			2014			2013
Numerator:
Net loss	$	(101,526	)	$	(62,479	)	$	(60,690	)
Accretion of preferred stock		—			(9,000	)		(17,471	)
Loss attributable to common stockholders—basic		(101,526	)		(71,479	)		(78,161	)
Effect of dilutive convertible preferred stock		—			—			—
Loss attributable to common stockholders—diluted	$	(101,526	)	$	(71,479	)	$	(78,161	)
Denominator:
Weighted-average number of common shares used in loss per share—diluted		39,643,099			17,699,487			383,310
Loss per share—basic and diluted	$	(2.56	)	$	(4.04	)	$	(203.91	)

Schedule of potentially dilutive securities excluded from the computation of diluted weighted-average shares outstanding

	Year Ended December 31
	2015		2014		2013
Convertible preferred stock		—		3,857,664		6,617,686
Options to purchase common stock		3,903,051		2,466,492		1,743,890
Warrants		822,726		1,271,520		545,797
Performance units		—		—		—