- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

+ References+ Details

License Agreements (Details)	3 Months Ended		12 Months Ended			3 Months Ended		12 Months Ended				3 Months Ended		12 Months Ended		3 Months Ended		12 Months Ended			3 Months Ended
License Agreements (Details)	Mar. 31, 2014 USD ($)	Mar. 31, 2013 USD ($)	Dec. 31, 2013 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Mar. 31, 2014 License agreement Ipsen USD ($)	Mar. 31, 2013 License agreement Ipsen USD ($)	Dec. 31, 2013 License agreement Ipsen USD ($)	Dec. 31, 2012 License agreement Ipsen USD ($)	Dec. 31, 2011 License agreement Ipsen USD ($)	Dec. 31, 2005 License agreement Ipsen USD ($)	Mar. 31, 2014 License agreement Ipsen Minimum USD ($)	Mar. 31, 2014 License agreement Ipsen Minimum EUR (€)	Dec. 31, 2013 License agreement Ipsen Minimum USD ($)	Dec. 31, 2013 License agreement Ipsen Minimum EUR (€)	Mar. 31, 2014 License agreement Ipsen Maximum USD ($)	Mar. 31, 2014 License agreement Ipsen Maximum EUR (€)	Dec. 31, 2013 License agreement Ipsen Maximum USD ($)	Dec. 31, 2013 License agreement Ipsen Maximum EUR (€)	Dec. 31, 2013 License agreement Ipsen Sublicense Agreement	Mar. 31, 2014 License agreement Ipsen Sublicense Agreement Minimum
License Agreements
Nonrefundable, non-creditable payment											$ 250,000
Additional payments to be made upon achievement of certain development and commercialization milestones												13,800,000	10,000,000	13,800,000	10,000,000	50,000,000	36,000,000	49,600,000	36,000,000
Royalty rate (as a percent)						5.00%		5.00%
Period after the date of the first commercial sale of the product for license expiration								10 years				10 years	10 years							10 years	10 years
Amount recorded in research and development expense	$ 9,717,000	$ 17,287,000	$ 60,536,000	$ 54,961,000	$ 36,179,000	$ 100,000	$ 100,000	$ 200,000	$ 700,000	$ 1,000,000