X0202 SCHEDULE 13G/A 0001622627-25-000017 0001622627 XXXXXXXX LIVE 3 Common Shares 3/31/2025 0001427925 TALPHERA, INC. 00444T209 1850 GATEWAY DRIVE 1850 GATEWAY DRIVE SAN MATEO CA 94404 Rule 13d-1(d) Rosalind Advisors, Inc. A6 0.00 12925597.00 0.00 12925597.00 12925597.00 9.9 CO This percentage is calculated based upon 51,899,648 ordinary shares of the Issuers common stock outstanding as of April 24th, 2026, based on the DEF 14A Filing on June 29th, 2026. However, as more fully described in Item 4, the securities reported in rows 6, 8 and 9 show the number of shares of Common Stock that would be issuable upon full conversion and exercise of such reported securities and do not give effect to such blockers. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person, after giving effect to such blockers, is less than the number of securities reported in rows 6, 8 and 9. (6) 3,353,916 shares of Common Stock 2,941,180 shares of Common Stock issuable upon exercise of warrants 6,630,501 shares of Common Stock issuable upon exercise of pre-funded warrants SALAMON STEVEN A J A6 0.00 12925597.00 0.00 12925597.00 12925597.00 9.9 IN (6) 3,353,916 shares of Common Stock 2,941,180 shares of Common Stock issuable upon exercise of warrants 6,630,501 shares of Common Stock issuable upon exercise of pre-funded warrants Aharon Gil A6 0.00 12925597.00 0.00 12925597.00 12925597.00 9.9 IN (6) 3,353,916 shares of Common Stock 2,941,180 shares of Common Stock issuable upon exercise of warrants 6,630,501 shares of Common Stock issuable upon exercise of pre-funded warrants Rosalind Master Fund L.P. E9 0.00 12925597.00 0.00 12925597.00 12925597.00 9.9 PN (6) 3,353,916 shares of Common Stock 2,941,180 shares of Common Stock issuable upon exercise of warrants 6,630,501 shares of Common Stock issuable upon exercise of pre-funded warrants TALPHERA, INC. 1850 GATEWAY DRIVE, 1850 GATEWAY DRIVE, SAN MATEO, CALIFORNIA, 94404. Rosalind Advisors Inc. Advisor to RMF Rosalind Master Fund L.P. RMF Steven Salamon President Steven Salamon is the portfolio manager of the Advisor which advises RMF. Gilad Aharon is the portfolio manager and member of the Advisor which advises RMF. Rosalind Advisors, Inc. 15 Wellesley Street West Suite 326 Toronto, Ontario M4Y 0G7 Canada Rosalind Master Fund L.P. P.O. Box 309 Ugland House, Grand Cayman KY1-1104, Cayman Islands Steven Salamon 15 Wellesley Street West Suite 326 Toronto, Ontario M4Y 0G7 Canada Gilad Aharon 15 Wellesley Street West Suite 326 Toronto, Ontario M4Y 0G7 Canada Mr. Salamon and Mr. Aharon are citizens of Canada, resident in Ontario N The information as of the date of the event which requires filing of this statement required by Items 4a to c is set forth in Rows 7 to 13 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. The percentage set forth in Row 11 of the cover page for each Reporting Person is based upon 51,899,648 ordinary shares of the Issuers common stock outstanding as of April 24th, 2026, based on the DEF 14A Filing on June 29th, 2026. Rosalind Master Fund L.P. may have been deemed to have the beneficial ownership of 3,353,916 shares of common stock representing the beneficial ownership of approximately 6.46% of the common stocks as mentioned above, which excludes the 9,571,681 shares issuable upon the exercise of pre-funded warrants and warrants because they contain a blocker provision under which the holder thereof does not have the right to exercise any of the warrant to the extent that such exercise would result in beneficial ownership by the holder in excess of 9.99% of the Common Stock. Consequently, as of the date of the event which requires the filing of this statement, the Reporting Persons were not able to exercise any of the warrants due to the Blockers. Rosalind Advisors Inc. is the investment advisor to RMF and may be deemed to be the beneficial owner of shares held by RMF. Steven Salamon is the portfolio manager of the Advisor and may be deemed to be the beneficial owner of shares held by RMF. Notwithstanding the foregoing, the Advisor and Mr. Salamon disclaim beneficial ownership of the shares. Rosalind Advisors Inc. 9.9% Rosalind Master Fund L.P. 9.9% Steven Salamon 9.9% Gilad Aharon 9.9% 0 Rosalind Advisors Inc. 3,353,916 Rosalind Master Fund L.P. 3,353,916 Steven Salamon 3,353,916 Gilad Aharon 3,353,916 0 Rosalind Advisors Inc. 3,353,916 Rosalind Master Fund L.P. 3,353,916 Steven Salamon 3,353,916 Gilad Aharon 3,353,916 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ? 240.14a-11. Rosalind Advisors, Inc. Steven Salamon 05/12/2026 SALAMON STEVEN A J Steven Salamon 05/12/2026 Aharon Gil Gil Aharon 05/12/2026 Rosalind Master Fund L.P. Mike McDonald 05/12/2026