Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Revenue:
Revenue	$ 2,289	$ 2,151	$ 7,995
Operating costs and expenses:
Cost of goods sold	6,806	3,976	10,659
Research and development	4,661	13,137	19,409
Selling, general and administrative	45,027	20,765	16,609
Total operating costs and expenses	56,494	37,878	46,677
Loss from operations	(54,205)	(35,727)	(38,682)
Other income (expense):
Interest expense	(2,535)	(2,217)	(3,316)
Interest income and other income (expense), net	2,166	1,138	510
Non-cash interest income (expense) on liability related to sale of future royalties	1,337	(10,341)	(10,721)
Total other income (expense)	968	(11,420)	(13,527)
Net loss before income taxes	(53,237)	(47,147)	(52,209)
Provision (benefit) for income taxes	3	2	(701)
Net loss	(53,240)	(47,149)	(51,508)
Other comprehensive loss:
Unrealized losses on available for sale securities			(3)
Comprehensive loss	$ (53,240)	$ (47,149)	$ (51,511)
Net loss per share of common stock, basic and diluted (in dollars per share)	$ (0.67)	$ (0.81)	$ (1.10)
Shares used in computing net loss per share of common stock, basic and diluted –see Note 13 (in shares)	79,184,266	58,408,548	46,883,535
Product [Member]
Revenue:
Revenue	$ 1,830	$ 825	$ 6,673
Contract and Other Collaboration [Member]
Revenue:
Revenue	$ 459	$ 1,326	$ 1,322