X0306 4 2022-03-03 0 0001427925 ACELRX PHARMACEUTICALS INC ACRX 0001628970 ASADORIAN RAFFI C/O ACELRX PHARMACEUTICALS, INC. 25821 INDUSTRIAL BLVD., SUITE 400 HAYWARD CA 94545 0 1 0 0 Chief Financial Officer Common Stock 2022-03-03 4 F 0 7923 0.4068 D 364205 D Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs. Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions. Balance includes non-reportable acquisition of 4,040 shares of Common Stock through the Company's Employee Stock Purchase Plan. On February 14, 2022, the reporting person filed a Form 4 which inadvertently under-reported his holdings in the Issuer by 8 shares. In addition to reporting the current transactions, this Form 4 serves to correct the reporting person's holdings in the Issuer. /s/ Martha Adler, Attorney-In-Fact 2022-03-04