X0306 4 2017-11-14 0 0001427925 ACELRX PHARMACEUTICALS INC ACRX 0001190429 EDWARDS MARK G C/O ACELRX PHARMACEUTICALS, INC. 351 GALVESTON DRIVE REDWOOD CITY CA 94063 1 0 0 0 Common Stock 2017-11-14 4 P 0 30000 1.899 A 150000 D The price reported on Column 4 is a weighted average price. These shares were purchased in multiple transactions ranging from $1.8923 to $1.90 on November 14, 2017. The reporting person will provide upon request to the SEC, the issuer or security holder of Issuer, full information regarding the number of shares purchased at each separate price. /s/ Martha Adler, Attorney-in-Fact 2017-11-14