Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation of Revenue [Line Items]
Total Revenues	$ 11,887	$ 11,703	$ 23,535	$ 22,776
Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	11,485	11,405	22,793	22,203
Other revenues
Disaggregation of Revenue [Line Items]
Total Revenues	203	139	355	272
Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	3,472	2,964	6,899	5,988
Alliance revenues | Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	3,273	2,805	6,512	5,687
Alliance revenues | Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	$ 199	$ 159	$ 387	$ 301