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Revenue
3 Months Ended
Mar. 31, 2022
Revenue from Contract with Customer [Abstract]  
Revenue REVENUE
The following table summarizes the disaggregation of revenue by nature:
Three Months Ended March 31,
Dollars in Millions20222021
Net product sales$11,308 $10,798 
Alliance revenues188 142 
Other revenues152 133 
Total Revenues$11,648 $11,073 

The following table summarizes GTN adjustments:
Three Months Ended March 31,
Dollars in Millions20222021
Gross product sales$16,650 $15,559 
GTN adjustments(a)
Charge-backs and cash discounts(1,763)(1,586)
Medicaid and Medicare rebates(2,084)(1,718)
Other rebates, returns, discounts and adjustments(1,495)(1,457)
Total GTN adjustments(5,342)(4,761)
Net product sales$11,308 $10,798 
(a)    Includes adjustments for provisions for product sales made in prior periods resulting from changes in estimates of $74 million and $217 million for the three months ended March 31, 2022, and 2021, respectively.

The following table summarizes the disaggregation of revenue by product and region:
Three Months Ended March 31,
Dollars in Millions20222021
In-Line Products
Eliquis$3,211 $2,886 
Opdivo1,923 1,720 
Pomalyst/Imnovid826 773 
Orencia792 758 
Sprycel483 470 
Yervoy515 456 
Empliciti75 85 
Mature and other products462 506 
New Product Portfolio
Reblozyl156 112 
Abecma67 — 
Zeposia36 18 
Breyanzi44 — 
Inrebic18 16 
Onureg23 15 
Opdualag— 
Recent LOE Products(a)
Revlimid2,797 2,944 
Abraxane214 314 
Total Revenues$11,648 $11,073 
United States$7,694 $7,010 
Europe2,413 2,553 
Rest of the World1,314 1,346 
Other(b)
227 164 
Total Revenues$11,648 $11,073 
(a)    Recent LOE Products includes products with significant decline in revenue from the prior reporting period as a result of a loss of exclusivity.
(b)    Other revenues include royalties and alliance-related revenues for products not sold by BMS’s regional commercial organizations.
Revenue recognized from performance obligations satisfied in prior periods was $147 million and $284 million for the three months ended March 31, 2022 and 2021, respectively, consisting primarily of revised estimates for GTN adjustments related to prior period sales and royalties for out-licensing arrangements.