Revenue - Disaggregation of Revenue by Product and Region (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenue from External Customer [Line Items]
Total Revenues	$ 11,648	$ 11,073
Performance obligation satisfied in previous period	147	284
United States
Revenue from External Customer [Line Items]
Total Revenues	7,694	7,010
Europe
Revenue from External Customer [Line Items]
Total Revenues	2,413	2,553
Rest of the World
Revenue from External Customer [Line Items]
Total Revenues	1,314	1,346
Other Region
Revenue from External Customer [Line Items]
Total Revenues	227	164
Eliquis
Revenue from External Customer [Line Items]
Total Revenues	3,211	2,886
Opdivo
Revenue from External Customer [Line Items]
Total Revenues	1,923	1,720
Pomalyst/Imnovid
Revenue from External Customer [Line Items]
Total Revenues	826	773
Orencia
Revenue from External Customer [Line Items]
Total Revenues	792	758
Sprycel
Revenue from External Customer [Line Items]
Total Revenues	483	470
Yervoy
Revenue from External Customer [Line Items]
Total Revenues	515	456
Empliciti
Revenue from External Customer [Line Items]
Total Revenues	75	85
Mature and other products
Revenue from External Customer [Line Items]
Total Revenues	462	506
Reblozyl
Revenue from External Customer [Line Items]
Total Revenues	156	112
Abecma
Revenue from External Customer [Line Items]
Total Revenues	67	0
Zeposia
Revenue from External Customer [Line Items]
Total Revenues	36	18
Breyanzi
Revenue from External Customer [Line Items]
Total Revenues	44	0
Inrebic
Revenue from External Customer [Line Items]
Total Revenues	18	16
Onureg
Revenue from External Customer [Line Items]
Total Revenues	23	15
Opdualag
Revenue from External Customer [Line Items]
Total Revenues	6	0
Revlimid
Revenue from External Customer [Line Items]
Total Revenues	2,797	2,944
Abraxane
Revenue from External Customer [Line Items]
Total Revenues	$ 214	$ 314