Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation of Revenue [Line Items]
Total Revenues	$ 11,648	$ 11,073
Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	11,308	10,798
Other revenues
Disaggregation of Revenue [Line Items]
Total Revenues	152	133
Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	3,427	3,024
Alliance revenues | Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	3,239	2,882
Alliance revenues | Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	$ 188	$ 142