CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands	Total		Common Stock	Additional Paid-In Capital	Other Comprehensive Loss	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021			77,962
Beginning balance at Dec. 31, 2021	$ 335,647		$ 78	$ 754,664	$ (129)	$ (418,966)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)			125
Issuance of common stock upon exercise of stock options	668			668
Stock-based compensation expense	7,820			7,820
Comprehensive gain (loss)	(548)				(548)
Net loss	(32,450)					(32,450)
Ending balance (in shares) at Mar. 31, 2022			78,087
Ending balance at Mar. 31, 2022	311,137		$ 78	763,152	(677)	(451,416)
Beginning balance (in shares) at Dec. 31, 2021			77,962
Beginning balance at Dec. 31, 2021	335,647		$ 78	754,664	(129)	(418,966)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Comprehensive gain (loss)	(948)
Net loss	(78,969)
Ending balance (in shares) at Jun. 30, 2022			79,463
Ending balance at Jun. 30, 2022	292,081		$ 79	791,014	(1,077)	(497,935)
Beginning balance (in shares) at Mar. 31, 2022			78,087
Beginning balance at Mar. 31, 2022	311,137		$ 78	763,152	(677)	(451,416)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under Open Market Sale Agreement, net of issuance costs (in shares)			1,144
Issuance of common stock under Open Market Sale Agreement, net of issuance costs	17,403		$ 1	17,402
Issuance of common stock under employee stock purchase plan (in shares)			121
Issuance of common stock under employee stock purchase plan	1,228			1,228
Issuance of common stock upon exercise of stock options (in shares)			103
Issuance of common stock upon exercise of stock options	993			993
Issuance of common stock to participants in 401(k) Plan (in shares)			8
Issuance of common stock to participants in 401(k) plan	137			137
Stock-based compensation expense	8,102			8,102
Comprehensive gain (loss)	(400)				(400)
Net loss	(46,519)					(46,519)
Ending balance (in shares) at Jun. 30, 2022			79,463
Ending balance at Jun. 30, 2022	292,081		$ 79	791,014	(1,077)	(497,935)
Beginning balance (in shares) at Dec. 31, 2022			81,885
Beginning balance at Dec. 31, 2022	259,560	[1]	$ 82	841,413	(302)	(581,633)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)			171
Issuance of common stock upon exercise of stock options	279			279
Stock-based compensation expense	8,537			8,537
Comprehensive gain (loss)	205				205
Net loss	(47,647)					(47,647)
Ending balance (in shares) at Mar. 31, 2023			82,056
Ending balance at Mar. 31, 2023	220,934		$ 82	850,229	(97)	(629,280)
Beginning balance (in shares) at Dec. 31, 2022			81,885
Beginning balance at Dec. 31, 2022	$ 259,560	[1]	$ 82	841,413	(302)	(581,633)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	351
Comprehensive gain (loss)	$ 153
Net loss	(85,908)
Ending balance (in shares) at Jun. 30, 2023			82,715
Ending balance at Jun. 30, 2023	192,121		$ 83	859,728	(149)	(667,541)
Beginning balance (in shares) at Mar. 31, 2023			82,056
Beginning balance at Mar. 31, 2023	220,934		$ 82	850,229	(97)	(629,280)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock under employee stock purchase plan (in shares)			352
Issuance of common stock under employee stock purchase plan	996		$ 1	995
Issuance of common stock upon exercise of stock options (in shares)			180
Issuance of common stock upon exercise of stock options	389			389
Issuance of common stock to participants in 401(k) Plan (in shares)			127
Issuance of common stock to participants in 401(k) plan	639			639
Stock-based compensation expense	7,476			7,476
Comprehensive gain (loss)	(52)				(52)
Net loss	(38,261)					(38,261)
Ending balance (in shares) at Jun. 30, 2023			82,715
Ending balance at Jun. 30, 2023	$ 192,121		$ 83	$ 859,728	$ (149)	$ (667,541)

[1] The condensed consolidated balance sheet as of December 31, 2022 has been derived from the audited financial statements as of that date.