X0202 SCHEDULE 13G/A 0001425738 XXXXXXXX LIVE 8 Common Shares, par value CHF 0.08 per share 04/20/2026 0001771910 ADC Therapeutics SA H0036K147 Biopole Route de la Corniche 3B Epalinges V8 1066 Rule 13d-1(c) Redmile Group, LLC DE 0.00 12717487.00 0.00 12717487.00 12717487.00 N 9.9 IA OO The information in Item 4 relating to the shares of Common Shares, par value CHF 0.08 per share, of the Issuer (the "Common Stock") that are or may be deemed beneficially owned by Redmile Group, LLC ("Redmile"), including RedCo II Offshore SPV LLC ("RedCo II SPV") is incorporated by reference herein. Percentage based on (i) 127,189,572 shares of Common Stock outstanding as of April 16, 2026, as reported by the Issuer in its Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934, as amended, filed with the Securities and Exchange Commission on April 20, 2026 (the "Proxy Statement") plus (ii) 112,602 shares of Common Stock issuable upon exercise of certain of the Pre-Funded Warrants to purchase Common Stock (the "Warrants") held directly by certain investment vehicles, including RedCo II SPV, managed by Redmile (the "Redmile Funds"), which due to the Beneficial Ownership Limitation (as defined in Item 4) is the maximum number of shares that could be issued to the Redmile Funds upon exercise of the Warrants. Jeremy C. Green X0 0.00 12717487.00 0.00 12717487.00 12717487.00 N 9.9 HC IN The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by Jeremy C. Green is incorporated by reference herein. Percentage based on (i) 127,189,572 shares of Common Stock outstanding as of April 16, 2026, as reported by the Issuer in its Proxy Statement plus (ii) 112,602 shares of Common Stock issuable upon exercise of certain of the Warrants held directly by the Redmile Funds, including RedCo II SPV, which due to the Beneficial Ownership Limitation (as defined in Item 4) is the maximum number of shares that could be issued to the Redmile Funds upon exercise of the Warrants. RedCo II Offshore SPV LLC E9 0.00 7780431.00 0.00 7780431.00 7780431.00 N 6.1 FI OO The information in Item 4 relating to the shares of Common Stock that are or may be deemed beneficially owned by RedCo II SPV is incorporated by reference herein. Percentage based on (i) 127,189,572 shares of Common Stock outstanding as of April 16, 2026, as reported by the Issuer in its Proxy Statement plus (ii) 112,602 shares of Common Stock issuable upon exercise of certain of the Warrants held directly by RedCo II SPV, which due to the Beneficial Ownership Limitation (as defined in Item 4) is the maximum number of shares that could be issued to RedCo II SPV upon exercise of the Warrants. RedCo II Master Fund, L.P. E9 0.00 0.00 0.00 0.00 0.00 N 0.0 PN FI Following the internal reorganization among certain Redmile Funds described in Item 4 below, RedCo II Master Fund, L.P. beneficially owned no shares of the Issuer's Common Stock. ADC Therapeutics SA Biopole Route de la Corniche 3B Epalinges, Switzerland 1066 Redmile Group, LLC Jeremy C. Green RedCo II Offshore SPV LLC RedCo II Master Fund, L.P. Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Jeremy C. Green c/o Redmile Group, LLC (NY Office) 45 W. 27th Street, Floor 11 New York, NY 10001 RedCo II Offshore SPV LLC c/o Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 RedCo II Master Fund, L.P. c/o Redmile Group, LLC 900 Larkspur Landing Circle, Suite 270 Larkspur, California 94939 Redmile Group, LLC: Delaware Jeremy C. Green: United Kingdom RedCo II Offshore SPV LLC: Cayman Islands RedCo II Master Fund, L.P.: Cayman Islands Y Redmile Group, LLC - 12,717,487 (1) Jeremy C. Green - 12,717,487 (1) RedCo II Offshore SPV LLC - 7,780,431 (2) RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 9.9% (3) Jeremy C. Green - 9.9% (3) RedCo II Offshore SPV LLC - 6.1% (4) RedCo II Master Fund, L.P. - 0.0% Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Offshore SPV LLC - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 12,717,487 (1) Jeremy C. Green - 12,717,487 (1) RedCo II Offshore SPV LLC - 7,780,431 (2) RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 0 Jeremy C. Green - 0 RedCo II Offshore SPV LLC - 0 RedCo II Master Fund, L.P. - 0 Redmile Group, LLC - 12,717,487 (1) Jeremy C. Green - 12,717,487 (1) RedCo II Offshore SPV LLC - 7,780,431 (2) RedCo II Master Fund, L.P. - 0 (1) As of April 20, 2026, Redmile Group, LLC's and Jeremy Green's beneficial ownership of the Issuer's Common Shares, par value CHF 0.08 per share (the "Common Stock"), is comprised of 12,604,885 shares of Common Stock owned by certain investment vehicles, including RedCo II Offshore SPV LLC ("RedCo II SPV"), for which Redmile Group, LLC ("Redmile") is the investment manager/adviser (the "Redmile Funds"). Subject to the Beneficial Ownership Blocker (as defined below), Redmile and Mr. Green may also be deemed to beneficially own 27,743,685 shares of Common Stock issuable upon exercise of certain Pre-Funded Warrants to purchase Common Stock (the "Warrants") held by the Redmile Funds, including RedCo II SPV. Pursuant to the terms of the Warrants, the Issuer may not effect any exercise of the Warrants, and a holder of any Warrants does not have the right to exercise the Warrant held by such holder, to the extent that after giving effect to such issuance after exercise, the holder (together with the holder's affiliates, and any other persons acting as a group together with the holder or any of the holder's affiliates), would beneficially own in excess of 9.99% (the "Beneficial Ownership Limitation") of the number of shares of Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock issued upon exercise of the Warrant (the "Beneficial Ownership Blocker"). The Beneficial Ownership Limitation may be changed at a holder's election upon 61 days' notice to the Issuer. The 12,717,487 shares of Common Stock reported as beneficially owned by Redmile in this Schedule 13G represent 9.99% of the outstanding shares of Common Stock (calculated in accordance with footnote (3) below) and includes 112,602 shares of Common Stock issuable under the Beneficial Ownership Blocker. The reported securities may also be deemed beneficially owned by Jeremy C. Green as the principal of Redmile. Redmile and Mr. Green each disclaim beneficial ownership of these securities, except to the extent of its or his pecuniary interest in such shares, if any. (2) On April 20, 2026, in connection with an internal reorganization of RedCo II Master Fund, L.P. ("RedCo II Master"), a private investment vehicle managed by Redmile, Redco II Master contributed all of its securities of the Issuer pro rata and in kind, for no consideration, to its two wholly-owned subsidiaries (collectively, the "SPVs"), including RedCo II SPV. As a result of the internal reorganization, (i) RedCo II Master ceased to have voting or dispositive power over any of the Issuer's securities and, therefore, is no longer a beneficial owner of more than 5% of the Issuer's Common Stock and will be dissolved, and (ii) RedCo II SPV became a beneficial owner of more than 5% of the Common Stock. The 7,780,431 shares of Common Stock reported as beneficially owned by RedCo II SPV includes 7,667,829 shares of Common Stock and 112,602 shares of Common Stock issuable upon exercise of the Warrants under the Beneficial Ownership Blocker. Accordingly, this Schedule 13G serves as an exit filing for RedCo II Master and as an initial filing for RedCo II SPV. The internal reorganization resulted in no change in the aggregate beneficial ownership of Redmile or Mr. Green. (3) Percentage for Redmile and Jeremy Green based on (i) 127,189,572 shares of Common Stock outstanding as of April 16, 2026, as reported by the Issuer in its Proxy Statement plus (ii) 112,602 shares of Common Stock issuable upon exercise of certain of the Warrants held directly by the Redmile Funds, including RedCo II SPV, which due to the Beneficial Ownership Limitation is the maximum number of shares that could be issued to the Redmile Funds upon exercise of the Warrants. (4) Percentage for RedCo II SPV based on (i) 127,189,572 shares of Common Stock outstanding as of April 16, 2026, as reported by the Issuer in its Proxy Statement plus (ii) 112,602 shares of Common Stock issuable upon exercise of certain of the Warrants held directly by RedCo II SPV, which due to the Beneficial Ownership Limitation (as defined in Item 4) is the maximum number of shares that could be issued to RedCo II SPV upon exercise of the Warrants. N Y Y N See the response to Item 4. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Redmile Group, LLC /s/ Jeremy C. Green 04/24/2026 Jeremy C. Green /s/ Jeremy C. Green 04/24/2026 RedCo II Offshore SPV LLC /s/ Jeremy C. Green 04/24/2026 RedCo II Master Fund, L.P. /s/ Jeremy C. Green 04/24/2026