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  <schemaVersion>X0202</schemaVersion>
  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001425738</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>09-30-2023</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>09-30-2023</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>Redmile Group, LLC</name>
        <address>
          <ns1:street1>One Letterman Drive</ns1:street1>
          <ns1:street2>Building D, Suite D3-300</ns1:street2>
          <ns1:city>San Francisco</ns1:city>
          <ns1:stateOrCountry>CA</ns1:stateOrCountry>
          <ns1:zipCode>94129</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-12776</form13FFileNumber>
      <crdNumber>000143606</crdNumber>
      <secFileNumber>801-67747</secFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>The attached information table excludes (a) 3,628 shares of common stock of IGM BIOSCIENCES INC issued pursuant to restricted stock unit awards, (b) 11,331 shares of common stock of FATE THERAPEUTICS INC issued pursuant to restricted stock unit awards, (c) 40,983 shares of common stock of SCIENCE 37 HOLDINGS, INC. issued pursuant to restricted stock unit awards and (d) 2,092 of common stock of AUGMEDIX, INC. issued pursuant to restricted stock unit awards.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Jennifer Ciresi</name>
      <title>General Counsel and Chief Compliance Officer</title>
      <phone>415-489-9980</phone>
      <signature>/s/ Jennifer Ciresi</signature>
      <city>San Francisco</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>11-14-2023</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>68</tableEntryTotal>
      <tableValueTotal>2101757147</tableValueTotal>
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