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  <schemaVersion>X0202</schemaVersion>
  <headerData>
    <submissionType>13F-HR</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001425738</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>03-31-2023</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>03-31-2023</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>Redmile Group, LLC</name>
        <address>
          <ns1:street1>One Letterman Drive</ns1:street1>
          <ns1:street2>Building D, Suite D3-300</ns1:street2>
          <ns1:city>San Francisco</ns1:city>
          <ns1:stateOrCountry>CA</ns1:stateOrCountry>
          <ns1:zipCode>94129</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F HOLDINGS REPORT</reportType>
      <form13FFileNumber>028-12776</form13FFileNumber>
      <crdNumber>000143606</crdNumber>
      <secFileNumber>801-67747</secFileNumber>
      <provideInfoForInstruction5>Y</provideInfoForInstruction5>
      <additionalInformation>The attached information table excludes (a) 2,644 shares of common stock of IGM BIOSCIENCES INC issued pursuant to restricted stock unit awards and (b) 2,681 shares of common stock of FATE THERAPEUTICS INC issued pursuant to restricted stock unit awards.</additionalInformation>
    </coverPage>
    <signatureBlock>
      <name>Jennifer Ciresi</name>
      <title>General Counsel and Chief Compliance Officer</title>
      <phone>415-489-9980</phone>
      <signature>/s/ Jennifer Ciresi</signature>
      <city>San Francisco</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>05-15-2023</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>0</otherIncludedManagersCount>
      <tableEntryTotal>76</tableEntryTotal>
      <tableValueTotal>2304694420</tableValueTotal>
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