SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Redmile Group, LLC

(Last) (First) (Middle)
ONE LETTERMAN DRIVE, BUILDING D,
SUITE D3-300

(Street)
SAN FRANCISCO CA 94129

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Syros Pharmaceuticals, Inc. [ SYRS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
07/06/2016
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/06/2016 C 84,760 A (1) 84,760 D(2)(3)
Common Stock 07/06/2016 C 47,486 A (1) 47,486 D(2)(4)
Common Stock 07/06/2016 C 262,069 A (1) 262,069 D(2)(5)
Common Stock 07/06/2016 C 31,447 A (1) 31,447 D(2)(6)
Common Stock 07/06/2016 C 40,420 A (1) 40,420 D(2)(7)
Common Stock 07/06/2016 P 144,383 A $12.5 191,869 D(2)(4)
Common Stock 07/06/2016 P 104,670 A $12.5 366,739 D(2)(5)
Common Stock 07/06/2016 P 174,320 A $12.5 205,767 D(2)(6)
Common Stock 07/06/2016 P 9,373 A $12.5 49,793 D(2)(7)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Preferred Stock (1) 07/06/2016 C 317,853 (1) (1) Common Stock 84,760 $0 0 D(2)(3)
Series B Preferred Stock (1) 07/06/2016 C 178,074 (1) (1) Common Stock 47,486 $0 0 D(2)(4)
Series B Preferred Stock (1) 07/06/2016 C 982,762 (1) (1) Common Stock 262,069 $0 0 D(2)(5)
Series B Preferred Stock (1) 07/06/2016 C 117,931 (1) (1) Common Stock 31,447 $0 0 D(2)(6)
Series B Preferred Stock (1) 07/06/2016 C 151,576 (1) (1) Common Stock 40,420 $0 0 D(2)(7)
1. Name and Address of Reporting Person*
Redmile Group, LLC

(Last) (First) (Middle)
ONE LETTERMAN DRIVE, BUILDING D,
SUITE D3-300

(Street)
SAN FRANCISCO CA 94129

(City) (State) (Zip)
1. Name and Address of Reporting Person*
Green Jeremy

(Last) (First) (Middle)
ONE LETTERMAN DRIVE, BUILDING D,
SUITE D3-300

(Street)
SAN FRANCISCO CA 94129

(City) (State) (Zip)
Explanation of Responses:
1. The Series B Preferred Stock converted into Common Stock on a 3.75-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Preferred Stock was convertible at any time at the holder's election and automatically upon the closing of the Issuer's initial public offering. The shares had no expiration date.
2. These securities are directly owned by certain private investment vehicles managed by Redmile Group, LLC ("Redmile") and may be deemed beneficially owned by Redmile as investment manager of such private investment vehicles. The reported securities may also be deemed beneficially owned by Jeremy Green as the principal of Redmile. The Reporting Persons disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein, and this report shall not be deemed an admission that such Reporting Persons are the beneficial owners of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.
3. These shares are owned directly by Redmile Biopharma Investments I, L.P.
4. These shares are owned directly by Redmile Capital Fund LP.
5. These shares are owned directly by Redmile Capital Offshore Fund II, Ltd.
6. These shares are owned directly by Redmile Capital Offshore Fund, Ltd.
7. These shares are owned directly by Redmile Special Opportunities Fund, Ltd.
Redmile Group, LLC By: /s/ Jeremy Green Name: Jeremy Green Title: Managing Member 07/06/2016
By: /s/ Jeremy Green Name: Jeremy Green 07/06/2016
** Signature of Reporting Person Date
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