Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Series A Convertible Preferred Stock Preferred Stock	Series B Convertible Preferred Stock Preferred Stock	Common Stock	Additional Paid-In Capital	Accumulated Comprehensive Income (Loss)	Accumulated Deficit	Total
Beginning Balance at Dec. 31, 2020		$ 4	$ 6	$ 1,486,662	$ 19	$ (830,193)	$ 656,498
Beginning Balance (in Shares) at Dec. 31, 2020	194	3,581,119	146,874,917
Stock-based compensation expense				50,661			50,661
Common stock issued upon purchase of employee stock purchase plan				970			970
Common stock issued upon purchase of employee stock purchase plan (in shares)			55,315
Common stock issued upon exercise of stock options				29,992			29,992
Common stock issued upon exercise of stock options (in shares)			2,559,361
Common stock sold in public offering, net of offering costs			$ 1	203,154			203,155
Common stock sold in public offering, net of offering costs (in shares)			6,474,099
Common stock issued from preferred stock conversion		$ (1)		1
Common stock issued from preferred stock conversion (in Shares)		(738,961)	738,961
Unrealized (loss) gain on investments					(24)		(24)
Net loss						(242,922)	(242,922)
Ending Balance at Sep. 30, 2021		$ 3	$ 7	1,771,440	(5)	(1,073,115)	698,330
Ending Balance (in Shares) at Sep. 30, 2021	194	2,842,158	156,702,653
Beginning Balance at Jun. 30, 2021		$ 3	$ 7	1,731,363	33	(986,993)	744,413
Beginning Balance (in Shares) at Jun. 30, 2021	194	2,842,158	154,799,721
Stock-based compensation expense				19,306			19,306
Common stock issued upon exercise of stock options				20,771			20,771
Common stock issued upon exercise of stock options (in shares)			1,902,932
Unrealized (loss) gain on investments					(38)		(38)
Net loss						(86,122)	(86,122)
Ending Balance at Sep. 30, 2021		$ 3	$ 7	1,771,440	(5)	(1,073,115)	698,330
Ending Balance (in Shares) at Sep. 30, 2021	194	2,842,158	156,702,653
Beginning Balance at Dec. 31, 2021		$ 3	$ 7	1,794,695	(601)	(1,172,445)	621,659
Beginning Balance (in Shares) at Dec. 31, 2021	194	2,842,158	157,004,742
Stock-based compensation expense				64,513			64,513
Common stock issued upon purchase of employee stock purchase plan				582			582
Common stock issued upon purchase of employee stock purchase plan (in shares)			80,203
Vesting of restricted shares issued for services (in shares)			898,392
Tax payments related to shares withheld for vested restricted stock units				(2,649)			(2,649)
Tax payments related to shares withheld for vested restricted stock units (Shares)			(346,335)
Common stock issued upon exercise of stock options				1,642			1,642
Common stock issued upon exercise of stock options (in shares)			203,579
Unrealized (loss) gain on investments					(1,437)		(1,437)
Net loss						(290,574)	(290,574)
Ending Balance at Sep. 30, 2022		$ 3	$ 7	1,858,783	(2,038)	(1,463,019)	393,736
Ending Balance (in Shares) at Sep. 30, 2022	194	2,842,158	157,840,581
Beginning Balance at Jun. 30, 2022		$ 3	$ 7	1,838,778	(2,697)	(1,363,401)	472,690
Beginning Balance (in Shares) at Jun. 30, 2022	194	2,842,158	157,800,581
Stock-based compensation expense				19,780			19,780
Common stock issued upon exercise of stock options				225			225
Common stock issued upon exercise of stock options (in shares)			40,000
Unrealized (loss) gain on investments					659		659
Net loss						(99,618)	(99,618)
Ending Balance at Sep. 30, 2022		$ 3	$ 7	$ 1,858,783	$ (2,038)	$ (1,463,019)	$ 393,736
Ending Balance (in Shares) at Sep. 30, 2022	194	2,842,158	157,840,581