Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Series A Convertible Preferred Stock Preferred Stock	Series B Convertible Preferred Stock Preferred Stock	Common Stock	Additional Paid-In Capital	Accumulated Comprehensive Income (Loss)	Accumulated Deficit	Total
Beginning Balance at Dec. 31, 2020		$ 4	$ 6	$ 1,486,662	$ 19	$ (830,193)	$ 656,498
Beginning Balance (in Shares) at Dec. 31, 2020	194	3,581,119	146,874,917
Stock-based compensation expense				31,355			31,355
Common stock issued upon purchase of employee stock purchase plan				970			970
Common stock issued upon purchase of employee stock purchase plan (in shares)			55,315
Common stock issued upon exercise of stock options				9,221			9,221
Common stock issued upon exercise of stock options (in shares)			656,429
Common stock sold in public offering, net of offering costs			$ 1	203,154			203,155
Common stock sold in public offering, net of offering costs (in shares)			6,474,099
Common stock issued from preferred stock conversion		$ (1)		1
Common stock issued from preferred stock conversion (in Shares)		(738,961)	738,961
Unrealized (loss) gain on investments					14		14
Net loss						(156,800)	(156,800)
Ending Balance at Jun. 30, 2021		$ 3	$ 7	1,731,363	33	(986,993)	744,413
Ending Balance (in Shares) at Jun. 30, 2021	194	2,842,158	154,799,721
Beginning Balance at Dec. 31, 2020		$ 4	$ 6	1,486,662	19	(830,193)	656,498
Beginning Balance (in Shares) at Dec. 31, 2020	194	3,581,119	146,874,917
Ending Balance at Dec. 31, 2021		$ 3	$ 7	1,794,695	(601)	(1,172,445)	621,659
Ending Balance (in Shares) at Dec. 31, 2021	194	2,842,158	157,004,742
Beginning Balance at Mar. 31, 2021		$ 3	$ 6	1,552,968	96	(905,642)	647,431
Beginning Balance (in Shares) at Mar. 31, 2021	194	2,842,158	149,315,299
Stock-based compensation expense				14,414			14,414
Common stock issued upon exercise of stock options				2,742			2,742
Common stock issued upon exercise of stock options (in shares)			233,251
Common stock sold in public offering, net of offering costs			$ 1	160,269			160,270
Common stock sold in public offering, net of offering costs (in shares)			5,195,856
Unrealized (loss) gain on investments					(63)		(63)
Net loss						(81,351)	(81,351)
Ending Balance at Jun. 30, 2021		$ 3	$ 7	1,731,363	33	(986,993)	744,413
Ending Balance (in Shares) at Jun. 30, 2021	194	2,842,158	154,799,721
Beginning Balance at Dec. 31, 2021		$ 3	$ 7	1,794,695	(601)	(1,172,445)	621,659
Beginning Balance (in Shares) at Dec. 31, 2021	194	2,842,158	157,004,742
Stock-based compensation expense				44,733			44,733
Vesting of restricted shares issued for services (in shares)			898,392
Tax payments related to shares withheld for vested restricted stock units				(2,649)			(2,649)
Tax payments related to shares withheld for vested restricted stock units (Shares)			(346,335)
Common stock issued upon exercise of stock options				1,417			1,417
Common stock issued upon exercise of stock options (in shares)			163,579
Unrealized (loss) gain on investments					(2,096)		(2,096)
Net loss						(190,956)	(190,956)
Ending Balance at Jun. 30, 2022		$ 3	$ 7	1,838,778	(2,697)	(1,363,401)	472,690
Ending Balance (in Shares) at Jun. 30, 2022	194	2,842,158	157,800,581
Beginning Balance at Mar. 31, 2022		$ 3	$ 7	1,818,377	(2,343)	(1,264,052)	551,992
Beginning Balance (in Shares) at Mar. 31, 2022	194	2,842,158	157,168,321
Stock-based compensation expense				22,468			22,468
Vesting of restricted shares issued for services (in shares)			898,392
Tax payments related to shares withheld for vested restricted stock units				(2,649)			(2,649)
Tax payments related to shares withheld for vested restricted stock units (Shares)			(346,335)
Unrealized (loss) gain on investments					(354)		(354)
Net loss						(99,349)	(99,349)
Ending Balance at Jun. 30, 2022		$ 3	$ 7	$ 1,838,778	$ (2,697)	$ (1,363,401)	$ 472,690
Ending Balance (in Shares) at Jun. 30, 2022	194	2,842,158	157,800,581