X0306 4 2016-02-04 0 0001425205 Lion Biotechnologies, Inc. LBIO 0001672639 Fischkoff Steven A. 112 WEST 34TH STREET, 17TH FLOOR NEW YORK NY 10120 0 1 0 0 Chief Medical Officer Stock Option 5.43 2016-02-04 4 A 0 225000 0 A 2026-02-04 Common Stock 225000 225000 D The option will vest as to 75,000 shares on February 4, 2017, and the remaining options shall vest as to 18,750 shares quarterly over the next two years after February 4, 2017, provided the Reporting Person is still providing services to the Issuer on the respective dates. /s/ Steven A. Fischkoff 2016-04-21