SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 3 Common Stock, par value $0.000041666 per share 03/31/2025 0001425205 Iovance Biotherapeutics, Inc. 462260100 825 Industrial Road Suite 100 San Carlos CA 94070 Rule 13d-1(c) Perceptive Advisors LLC DE 0 12808788 0 12808788 12808788 N 3.8 IA Joseph Edelman X1 0 12808788 0 12808788 12808788 N 3.8 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 12808788 0 12808788 12808788 N 3.8 CO Iovance Biotherapeutics, Inc. 825 Industrial Road, Suite 400, San Carlos, CA 94070 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.00041666 per share (the "Common Stock") of Iovance Biotherapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 333,934,387 shares of Common Stock outstanding as of April 30, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 8, 2025, and assume of the conversion of preferred stock held by the Reporting Persons into 97,000 shares of Common Stock. The Master Fund directly holds 12,711,982 shares of Common Stock and preferred stock convertible into 97,000 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors: 3.8% Mr. Edelman: 3.8% Master Fund: 3.8 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 12,808,788 Mr. Edelman: 12,808,788 Master Fund: 12,808,788 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 12,808,788 Mr. Edelman: 12,808,788 Master Fund: 12,808,788 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2025 Joseph Edelman /s/ Joseph Edelman 05/15/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/15/2025