<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001424342</cik>
        <entityName>Phenomix CORP</entityName>
        <issuerAddress>
            <street1>5930 CORNERSTONE COURT WEST, SUITE 230</street1>
            <city>SAN DIEGO</city>
            <stateOrCountry>CA</stateOrCountry>
            <zipCode>92121</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(858) 731-5225</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Laura</firstName>
                <lastName>Shawver</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Brian</firstName>
                <lastName>Baker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Angela</firstName>
                <lastName>Birchler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hans-Peter</firstName>
                <lastName>Guler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Marie</firstName>
                <lastName>O'Farrell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Diekman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Anton</firstName>
                <middleName>Giorgio</middleName>
                <lastName>Failla</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <lastName>Harper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <lastName>Harris</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Daniel</firstName>
                <lastName>Janney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Deepika</firstName>
                <lastName>Pakianathan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Damion</firstName>
                <middleName>E.</middleName>
                <lastName>Wicker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Phenomix Corporation</street1>
                <street2>5930 Cornerstone Court West, Suite 230</street2>
                <city>San Diego</city>
                <stateOrCountry>CA</stateOrCountry>
                <zipCode>92121</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-02-28</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>14889842</totalOfferingAmount>
            <totalAmountSold>5955935</totalAmountSold>
            <totalRemaining>8933907</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>31</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Proceeds from the offering will be used for general working capital.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Phenomix CORP</issuerName>
                <signatureName>/s/ Brian Baker</signatureName>
                <nameOfSigner>Brian Baker</nameOfSigner>
                <signatureTitle>Vice President, Finance</signatureTitle>
                <signatureDate>2010-03-05</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
