X0306 4 2016-01-04 0 0001423824 ALDER BIOPHARMACEUTICALS INC ALDR 0001604834 Litton Mark James 11804 NORTH CREEK PARKWAY SOUTH BOTHELL WA 98011 0 1 0 0 Chief Business Officer Common Stock 2016-01-04 4 M 0 25000 0.385 A 98718 D Common Stock 2016-01-04 4 S 0 17291 31.1942 D 81427 D Common Stock 2016-01-04 4 S 0 7709 31.8553 D 73718 D Common Stock 30000 I Held in trust for the benefit of Reporting Person's minor child Common Stock 30000 I Held in trust for the benefit of Reporting Person's minor child Common Stock 30000 I Held in trust for the benefit of Reporting Person's minor child Stock Option (Right to Buy) 0.385 2016-01-04 4 M 0 25000 0.00 D 2016-09-14 Common Stock 25000 50000 D The exercise of options reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 15, 2015. Includes 799 shares acquired under the Issuer's 2014 Employee Stock Purchase Plan on November 30, 2015. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 15, 2015. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.60 to $31.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 4 to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.60 to $32.36, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote 5 to this Form 4. The option is fully vested. /s/ Mark J. Litton 2016-01-06