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  <xs:element id="agnc_OtherAssetsAndOtherLiabilitiesAbstract" abstract="true" name="OtherAssetsAndOtherLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_OtherAssetsAndOtherLiabilitiesDisclosureTextBlock" abstract="false" name="OtherAssetsAndOtherLiabilitiesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_PledgedAssetsAbstract" abstract="true" name="PledgedAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_PledgedAssetsTextBlock" abstract="false" name="PledgedAssetsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_NetIncomeLossPerCommonShareAbstract" abstract="true" name="NetIncomeLossPerCommonShareAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DirectorPlanAbstract" abstract="true" name="DirectorPlanAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_NarrativeAbstract" abstract="true" name="NarrativeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" abstract="true" name="DiscontinuationOfElectionToAccountForInterestRateSwapsAsDesignatedCashFlowHedgesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_InterestIncomePolicyTextBlock" abstract="false" name="InterestIncomePolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ManagementAgreementTextBlock" abstract="false" name="ManagementAgreementTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ReverseRepurchaseAgreementsPolicyPolicyTextBlock" abstract="false" name="ReverseRepurchaseAgreementsPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_SecuritiesbyCreditRatingTableTextBlock" abstract="false" name="SecuritiesbyCreditRatingTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ComponentsOfInvestmentSecuritiesTableTextBlock" abstract="false" name="ComponentsOfInvestmentSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" abstract="false" name="SummaryofMortgageBackedSecuritiesEstimatedWeightedAverageLifeClassificationsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" abstract="false" name="SummaryOfContinuousUnrealizedLossPositionOfAvailableForSaleSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" abstract="false" name="SummaryofNetGainfromSaleofMortgageBackedSecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfMortgageBackedSecuritiesAgencyConcentrationTableTextBlock" abstract="false" name="ScheduleOfMortgageBackedSecuritiesAgencyConcentrationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" abstract="false" name="ScheduleOfBorrowingsUnderRepurchaseAgreementsAndWeightedAverageInterestRatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" abstract="false" name="ScheduleofFederalHomeLoanBankAdvancesandWeightedAverageInterestRatesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock" abstract="false" name="ScheduleofInterestRateSwapAgreementbyReceiveIndexasapercentageofNotionalAmountTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" abstract="false" name="ScheduleOfOutstandingDerivativesNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" abstract="false" name="ScheduleOfInterestRateSwapAgreementByRemainingMaturityTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" abstract="false" name="ScheduleOfInterestRateSwaptionAgreementsOutstandinTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_USgovernmentsecuritiesTableTextBlock" abstract="false" name="USgovernmentsecuritiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" abstract="false" name="ScheduleOfLongAndShortPositionOfDerivativeInstrumentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" abstract="false" name="ScheduleOfOutstandingNotDesignatedAsHedgingInstrumentsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_OtherAssetsTableTextBlock" abstract="false" name="OtherAssetsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock" abstract="false" name="ScheduleofSecuritiesandCashPledgedasCollateralfromCounterpartiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" abstract="false" name="SchedulesOfSecuritiesPledgedAsCollateralUnderRepurchaseAgreementTextBlockTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_PreferredStockTableTextBlock" abstract="false" name="PreferredStockTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" abstract="false" name="ScheduleOfTaxTreatmentOfDistributionsPerShareTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="agnc_EquityIncentivePlanAbstract" abstract="true" name="EquityIncentivePlanAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_RequiredAnnualDistributionOfTaxableNetIncome" abstract="false" name="RequiredAnnualDistributionOfTaxableNetIncome" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_IntendedAnnualDistributionofTaxableNetIncome" abstract="false" name="IntendedAnnualDistributionofTaxableNetIncome" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_VariableInterestEntitiesAbstract" abstract="true" name="VariableInterestEntitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_SpreadOverLibor" abstract="false" name="SpreadOverLibor" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_WeightedAverageLifeOtherDebt" abstract="false" name="WeightedAverageLifeOtherDebt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="agnc_ScheduleOfInvestmentSecuritiesByIssuerTable" abstract="true" name="ScheduleOfInvestmentSecuritiesByIssuerTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" abstract="true" name="TbaSecuritiesFifteenYearAndThirtyYearSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ForwardSettlingNonAgencySecuritiesMember" abstract="true" name="ForwardSettlingNonAgencySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_InterestOnlyAndPrincipalOnlyStripMember" abstract="true" name="InterestOnlyAndPrincipalOnlyStripMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_FuturePrepaymentRateAssumptionOfInvestmentPortfolio" abstract="false" name="FuturePrepaymentRateAssumptionOfInvestmentPortfolio" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_WeightedAverageCouponRate" abstract="false" name="WeightedAverageCouponRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_UnderlyingCollateralCoupon" abstract="false" name="UnderlyingCollateralCoupon" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" abstract="false" name="SecuritiesRemeasuredatFairValueThroughEarningsDebtSecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_FairValueOfCmoSecuritiesDirectlyHeld" abstract="false" name="FairValueOfCmoSecuritiesDirectlyHeld" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_SecuritizedCmoSecurities" abstract="false" name="SecuritizedCmoSecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" abstract="false" name="CmoAndInterestOnlyPricincipalOnlySecuritiesMaximumLossExposure" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_MortgageCreditInvestmentFundLimitedPartnership" abstract="false" name="MortgageCreditInvestmentFundLimitedPartnership" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AdjustableRateMember" abstract="true" name="AdjustableRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" abstract="false" name="DebtSecuritiesTradingandAvailableforsaleAmortizedCostBasis" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_TotalAgencySecurities" abstract="false" name="TotalAgencySecurities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NonAgencyMember" abstract="true" name="NonAgencyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_TradingSecuritiesMember" abstract="true" name="TradingSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_SecuritiesRemeasuredatFairValueMember" abstract="true" name="SecuritiesRemeasuredatFairValueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_SecurityTypeAxis" abstract="true" name="SecurityTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_SecurityTypeDomain" abstract="true" name="SecurityTypeDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesPar" abstract="false" name="AvailableForSaleSecuritiesPar" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesAvailableForSaleUnamortizedDiscount" abstract="false" name="DebtSecuritiesAvailableForSaleUnamortizedDiscount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesAvailableForSaleUnamortizedPremium" abstract="false" name="DebtSecuritiesAvailableForSaleUnamortizedPremium" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" abstract="false" name="DebtSecuritiesAvailableForSaleGrossUnrealizedLosses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedGains" abstract="false" name="DebtSecuritiesTradingSecuritiesGrossUnrealizedGains" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesTradingSecuritiesGrossUnrealizedLosses" abstract="false" name="DebtSecuritiesTradingSecuritiesGrossUnrealizedLosses" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_TradingSecuritiesPar" abstract="false" name="TradingSecuritiesPar" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesTradingSecuritiesUnamortizedDiscount" abstract="false" name="DebtSecuritiesTradingSecuritiesUnamortizedDiscount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesTradingSecuritiesUnamortizedPremium" abstract="false" name="DebtSecuritiesTradingSecuritiesUnamortizedPremium" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_WeightedAverageYieldPercentage" abstract="false" name="WeightedAverageYieldPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_MortgageBackedSecuritiesAmortizedCost" abstract="false" name="MortgageBackedSecuritiesAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_DebtSecuritiesAvailableForSaleGrossUnrealizedGains" abstract="false" name="DebtSecuritiesAvailableForSaleGrossUnrealizedGains" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AgencyMortgageBackedSecuritiesMember" abstract="true" name="AgencyMortgageBackedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ScheduleOfInvestmentSecuritiesByIssuerLineItems" abstract="true" name="ScheduleOfInvestmentSecuritiesByIssuerLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_LessThanorEqualtoThreeYearsMember" abstract="true" name="LessThanorEqualtoThreeYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" abstract="true" name="GreaterThanThreeYearsAndLessThanOrEqualToFiveYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanFiveYearsMember" abstract="true" name="GreaterThanFiveYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanTenYearsMember" abstract="true" name="GreaterThanTenYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeFairValue" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeCouponRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesWeightedAverageLifeYield" abstract="false" name="AvailableForSaleSecuritiesWeightedAverageLifeYield" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_AccumulatedOtherComprehensiveIncomeLossRollForward" abstract="true" name="AccumulatedOtherComprehensiveIncomeLossRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" abstract="false" name="OtherComprehensiveIncomeReclassificationAdjustmentForSaleOfSecurityReversalOfPriorPeriodUnrealizedGainAndLossesOnRealization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CostandProceedsofInvestmentSecuritiesMember" abstract="true" name="CostandProceedsofInvestmentSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GrossGainLossofInvestmentSecuritiesMember" abstract="true" name="GrossGainLossofInvestmentSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GainLossOnOtherDebt" abstract="false" name="GainLossOnOtherDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CostOfSaleOfAvailableForSaleSecuities" abstract="false" name="CostOfSaleOfAvailableForSaleSecuities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CostofSaleofFairValueOptionSecurities" abstract="false" name="CostofSaleofFairValueOptionSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CostofSaleofInvestmentSecurities" abstract="false" name="CostofSaleofInvestmentSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ProceedsFromSaleOfDebtSecurities" abstract="false" name="ProceedsFromSaleOfDebtSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ProceedsFromSaleOfDebtSecuritiesTrading" abstract="false" name="ProceedsFromSaleOfDebtSecuritiesTrading" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PrincipalPaymentsReceivedOnAvailableForSaleSecurities" abstract="false" name="PrincipalPaymentsReceivedOnAvailableForSaleSecurities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CreditRatingAxis" abstract="true" name="CreditRatingAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_CreditRatingDomain" abstract="true" name="CreditRatingDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_BBBRatingMember" abstract="true" name="BBBRatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_BBRatingMember" abstract="true" name="BBRatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AAARatingMember" abstract="true" name="AAARatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AARatingMember" abstract="true" name="AARatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ARatingMember" abstract="true" name="ARatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_BRatingMember" abstract="true" name="BRatingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_NotRatedMember" abstract="true" name="NotRatedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember" abstract="true" name="AgencySecuritiesRemeasuredAtFairValueThroughEarningsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_BethesdaSecuritiesMember" abstract="true" name="BethesdaSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_FICCMember" abstract="true" name="FICCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_TBAAndForwardSettlingSecuritiesMember" abstract="true" name="TBAAndForwardSettlingSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PercentageofRepurchaseAgreementFunding" abstract="false" name="PercentageofRepurchaseAgreementFunding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_WeightedAverageForwardStartDate" abstract="false" name="WeightedAverageForwardStartDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="agnc_WeightedAverageForwardStartDays" abstract="false" name="WeightedAverageForwardStartDays" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="agnc_RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" abstract="false" name="RepurchaseAgreementsExtinguishedExtinguishmentOfDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" abstract="false" name="WeightedAverageRemainingMaturityOfRepurchaseAgreementsExtinguishedExtinguishedDebt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="agnc_WeightedAverageInterestRateOfRepurchaseAgreementsExtinguishedExtinguishedDebt" abstract="false" name="WeightedAverageInterestRateOfRepurchaseAgreementsExtinguishedExtinguishedDebt" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_ThirtyOneToNinetyMember" abstract="true" name="ThirtyOneToNinetyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A4to6MonthsMember" abstract="true" name="A4to6MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A7to9monthsMember" abstract="true" name="A7to9monthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A10to12MonthsMember" abstract="true" name="A10to12MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A13to24MonthsMember" abstract="true" name="A13to24MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A25to36monthsMember" abstract="true" name="A25to36monthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A37to48monthsMember" abstract="true" name="A37to48monthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A49to60MonthsMember" abstract="true" name="A49to60MonthsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A2Daysto1MonthMember" abstract="true" name="A2Daysto1MonthMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_RepurchaseAgreementsWeightedAverageDaysToMaturity" abstract="false" name="RepurchaseAgreementsWeightedAverageDaysToMaturity" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="agnc_FederalHomeLoanBankAdvancesbyMaturityAbstract" abstract="true" name="FederalHomeLoanBankAdvancesbyMaturityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_FederalHomeLoanBankAdvancesMaturityPeriodAxis" abstract="true" name="FederalHomeLoanBankAdvancesMaturityPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_FederalHomeLoanBankAdvancesMaturityPeriodDomain" abstract="true" name="FederalHomeLoanBankAdvancesMaturityPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_OtherDerivativesMember" abstract="true" name="OtherDerivativesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_SOFRFuturesContractsMember" abstract="true" name="SOFRFuturesContractsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DerivativePositionAxis" abstract="true" name="DerivativePositionAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DerivativePositionDomain" abstract="true" name="DerivativePositionDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DerivativeInstrumentsDesignationAxis" abstract="true" name="DerivativeInstrumentsDesignationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DerivativeInstrumentsDesignationDomain" abstract="true" name="DerivativeInstrumentsDesignationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AtCostBasisMember" abstract="true" name="AtCostBasisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AtCarryingValueMember" abstract="true" name="AtCarryingValueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" abstract="false" name="CashFlowHedgesDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsAverageMonthsToExpiration" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" abstract="false" name="NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsAdditionsDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" abstract="false" name="NotionalAmountOfDerivativesNotDesignatedAsHedgingInstrumentsSettlementExpirationDuringPeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_OptionsAtCost" abstract="false" name="OptionsAtCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" abstract="false" name="InterestRateDerivativeNotDesignatedAsHedgingInstrumentsReceiveRate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_TradingSecuritiesAddedDuringthePeriod" abstract="false" name="TradingSecuritiesAddedDuringthePeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" abstract="false" name="NotionalAmountOfTradingSecuritiesSettlementExpirationDuringThePeriod" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CreditDefaultSwaps" abstract="false" name="CreditDefaultSwaps" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_SaleOfTBAAndForwardSettlingSecuritiesMember" abstract="true" name="SaleOfTBAAndForwardSettlingSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PurchasesOfTBAsAndForwardSettlingSecuritiesMember" abstract="true" name="PurchasesOfTBAsAndForwardSettlingSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_Governmentbondsownedandsoldshortnet" abstract="false" name="Governmentbondsownedandsoldshortnet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_OtherDerivativeAsset" abstract="false" name="OtherDerivativeAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NetFairValueOfInterestRateSwapsExcludingTheRecognitionOfVariationMarginSettlementsAsAReductionOfCarryingValue" abstract="false" name="NetFairValueOfInterestRateSwapsExcludingTheRecognitionOfVariationMarginSettlementsAsAReductionOfCarryingValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_BermudanMember" abstract="true" name="BermudanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_LessThanOrEqualToOneYearMember" abstract="true" name="LessThanOrEqualToOneYearMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" abstract="true" name="GreaterThanOneYearandLessThanorEqualtoTwoYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" abstract="true" name="GreaterThanTwoYearsandLessThanorEqualtoThreeYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" abstract="true" name="GreaterThanOneYearAndLessThanOrEqualToThreeYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" abstract="true" name="GreaterThanFiveYearsAndLessThanOrEqualToSevenYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" abstract="true" name="GreaterThanSevenYearsAndLessThanOrEqualToTenYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" abstract="true" name="GreaterThanThreeYearsAndLessThanOrEqualToFourYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PayerSwaptionMember" abstract="true" name="PayerSwaptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_InterestRateSwapsExcludingForwardStartingMember" abstract="true" name="InterestRateSwapsExcludingForwardStartingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ReceiverSwaptionMember" abstract="true" name="ReceiverSwaptionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_InterestRateSwapsLinkedtoOvernightIndexSwapRate" abstract="false" name="InterestRateSwapsLinkedtoOvernightIndexSwapRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_InterestRateSwapsLinkedto3MonthLIBOR" abstract="false" name="InterestRateSwapsLinkedto3MonthLIBOR" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" abstract="false" name="InterestRateSwapsLinkedtoSecuredOvernightFinancingRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_InterestRateReceiveSwapMember" abstract="true" name="InterestRateReceiveSwapMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A5YearMaturityMember" abstract="true" name="A5YearMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A20YearMaturityMember" abstract="true" name="A20YearMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A2.5CouponMember" abstract="true" name="A2.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A7YearsMaturityMember" abstract="true" name="A7YearsMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A15YearMaturityMember" abstract="true" name="A15YearMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AtParValueMember" abstract="true" name="AtParValueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_LessThanOrEqualToFiveYearsMember" abstract="true" name="LessThanOrEqualToFiveYearsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DerivativeByMaturityYearsAxis" abstract="true" name="DerivativeByMaturityYearsAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DerivativeByMaturityYearsDomain" abstract="true" name="DerivativeByMaturityYearsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A30YearMaturityMember" abstract="true" name="A30YearMaturityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DerivativesbyIssuerAxis" abstract="true" name="DerivativesbyIssuerAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_DerivativesbyIssuerDomain" abstract="true" name="DerivativesbyIssuerDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A6.5CouponMember" abstract="true" name="A6.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A5.5CouponMember" abstract="true" name="A5.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A5.0CouponMember" abstract="true" name="A5.0CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A20CouponMember" abstract="true" name="A20CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A3.0CouponMember" abstract="true" name="A3.0CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A3.5CouponMember" abstract="true" name="A3.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A4.0CouponMember" abstract="true" name="A4.0CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A4.5CouponMember" abstract="true" name="A4.5CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A3040CouponsMember" abstract="true" name="A3040CouponsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A4555CouponsMember" abstract="true" name="A4555CouponsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_A60CouponMember" abstract="true" name="A60CouponMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_InterestrateswapreceiverMember" abstract="true" name="InterestrateswapreceiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PurchasesOfForwardSettlingNonAgencySecuritiesMember" abstract="true" name="PurchasesOfForwardSettlingNonAgencySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ChangesinDerivativeandOtherHedgePortfolioRollForward" abstract="true" name="ChangesinDerivativeandOtherHedgePortfolioRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_OtherAssetsLineItems" abstract="true" name="OtherAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_ReceivableForUnsettledTransactions" abstract="false" name="ReceivableForUnsettledTransactions" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_VentureCapitalInvestments" abstract="false" name="VentureCapitalInvestments" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_OtherAssetsOther" abstract="false" name="OtherAssetsOther" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_CashPledgedFromCounterparties" abstract="false" name="CashPledgedFromCounterparties" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PayableForUnsettledTransactions" abstract="false" name="PayableForUnsettledTransactions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_OtherLiabilitiesOther" abstract="false" name="OtherLiabilitiesOther" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" abstract="false" name="RetainedInterestsinConsolidatedVIEsPledgedasCollateralUnderRepurchaseAgreements" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_RiskOfRepurchaseAgreementToStockholdersEquity" abstract="false" name="RiskOfRepurchaseAgreementToStockholdersEquity" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" abstract="true" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_J.P.MorganSecuritiesLLCMember" abstract="true" name="J.P.MorganSecuritiesLLCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" abstract="true" name="RepurchaseAgreementswithCounterpartiesGreaterthanorequalto5ofEquityatRiskLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_CounterpartyExposureNet" abstract="false" name="CounterpartyExposureNet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_RepurchaseAgreementsWeightedAverageMonthsToMaturity" abstract="false" name="RepurchaseAgreementsWeightedAverageMonthsToMaturity" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="agnc_OffsettingAssetsAndLiabilitiesTable" abstract="true" name="OffsettingAssetsAndLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_UnderPrimeBrokerAgreementsMember" abstract="true" name="UnderPrimeBrokerAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_ExcludingCashReceivedMember" abstract="true" name="ExcludingCashReceivedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DerivativeAgreementsAndOtherMember" abstract="true" name="DerivativeAgreementsAndOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_IncludesSoldButNotYetSettledSecuritiesMember" abstract="true" name="IncludesSoldButNotYetSettledSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AAANonAgencyMortgageBackedSecuritiesMember" abstract="true" name="AAANonAgencyMortgageBackedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_OffsettingAssetsAndLiabilitiesLineItems" abstract="true" name="OffsettingAssetsAndLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" abstract="false" name="AvailableForSaleSecuritiesPledgedAsCollateralAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_TotalFairValueofSecuritiesPledgedandAccruedInterest" abstract="false" name="TotalFairValueofSecuritiesPledgedandAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" abstract="false" name="TotalFairValueOfAgencySecuritiesPledgedAndAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_SecuritiesOwnedAndPledgedAsCollateralFairValue" abstract="false" name="SecuritiesOwnedAndPledgedAsCollateralFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_Maturity31To59DaysMember" abstract="true" name="Maturity31To59DaysMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_Maturity60To90DaysMember" abstract="true" name="Maturity60To90DaysMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AgencySecuritiesPledgedAsCollateralAmortizedCost" abstract="false" name="AgencySecuritiesPledgedAsCollateralAmortizedCost" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_AgencySecuritiesPledgedAsCollateralAccruedInterest" abstract="false" name="AgencySecuritiesPledgedAsCollateralAccruedInterest" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_ReverseRepurchaseAgreementsMember" abstract="true" name="ReverseRepurchaseAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AssetsPledgedtoUsMember" abstract="true" name="AssetsPledgedtoUsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_RestrictedCashandSecuritiesPledged" abstract="false" name="RestrictedCashandSecuritiesPledged" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_GrossAmountOfRecognizedAssetsLiabilities" abstract="false" name="GrossAmountOfRecognizedAssetsLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_GrossAmountOffsetintheConsolidatedBalanceSheets" abstract="false" name="GrossAmountOffsetintheConsolidatedBalanceSheets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" abstract="false" name="NetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" abstract="false" name="GrossAmountsofFinancialInstrumentsNotOffsetontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" abstract="false" name="GrossAmountsofCashCollateralNotOffsetontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" abstract="false" name="NetAmountAfterDeductingGrossAmountsNotOffsetontheBalanceSheetFromNetAmountofAssetsLiabilitiesPresentedontheBalanceSheet" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_TransfersBetweenHierarchyLevels" abstract="false" name="TransfersBetweenHierarchyLevels" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_WeightedAverageNumberofSharesOutstanding" abstract="false" name="WeightedAverageNumberofSharesOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" abstract="false" name="WeightedAverageNumberofFullyVestedRestrictedStockUnitsandPerformanceShareUnitsOutstanding" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_DepositaryShareMember" abstract="true" name="DepositaryShareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PreferredStockBValueIssued" abstract="false" name="PreferredStockBValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockPercentInterestPerShare" abstract="false" name="PreferredStockPercentInterestPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_PreferredStockEValueIssued" abstract="false" name="PreferredStockEValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockELiquidationPreferenceValue" abstract="false" name="PreferredStockELiquidationPreferenceValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockDividendPaymentRateVariableRateSpread" abstract="false" name="PreferredStockDividendPaymentRateVariableRateSpread" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_PreferredStockFValueIssued" abstract="false" name="PreferredStockFValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockDValueIssued" abstract="false" name="PreferredStockDValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockAuthorizedButNotIssued" abstract="false" name="PreferredStockAuthorizedButNotIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_PreferredStockCValueIssued" abstract="false" name="PreferredStockCValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockGValueIssued" abstract="false" name="PreferredStockGValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_PreferredStockDividednRatePercentageBasisSpread" abstract="false" name="PreferredStockDividednRatePercentageBasisSpread" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_PreferredStockHValueIssued" abstract="false" name="PreferredStockHValueIssued" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" abstract="false" name="StockRepurchasedDuringPeriodAverageRepurchasePriceindollarspershare" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodTradeDateShares" abstract="false" name="StockRepurchasedDuringPeriodTradeDateShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodTradeDateValue" abstract="false" name="StockRepurchasedDuringPeriodTradeDateValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodSettledAfterPeriodValue" abstract="false" name="StockRepurchasedDuringPeriodSettledAfterPeriodValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockRepurchasedDuringPeriodSettledAfterShares" abstract="false" name="StockRepurchasedDuringPeriodSettledAfterShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_CommonstockValueofSharesRemainingforFutureIssuance" abstract="false" name="CommonstockValueofSharesRemainingforFutureIssuance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_FollowOnPublicOfferingMember" abstract="true" name="FollowOnPublicOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_CommonStockAtTheMarketSaleAgreementMember" abstract="true" name="CommonStockAtTheMarketSaleAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_CommonstockValueofSharesApprovedforFutureIssuance" abstract="false" name="CommonstockValueofSharesApprovedforFutureIssuance" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="agnc_StockIssuedDuringPeriodPricePerShare" abstract="false" name="StockIssuedDuringPeriodPricePerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_ScheduleofDividendsDeclaredAbstract" abstract="true" name="ScheduleofDividendsDeclaredAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_OrdinaryDividendsPerShare" abstract="false" name="OrdinaryDividendsPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_LongTermCapitalGainDividendPerShare" abstract="false" name="LongTermCapitalGainDividendPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_NonDividendDistributionsPerShare" abstract="false" name="NonDividendDistributionsPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_Section199ADividendsPerShare" abstract="false" name="Section199ADividendsPerShare" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_OrdinaryDividendsPreferredStockAsAPercentage" abstract="false" name="OrdinaryDividendsPreferredStockAsAPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_A2016EquityPlanMember" abstract="true" name="A2016EquityPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_DirectorPlanMember" abstract="true" name="DirectorPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PerformanceadjustmentMember" abstract="true" name="PerformanceadjustmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_IssuedToAxis" abstract="true" name="IssuedToAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_IssuedToDomain" abstract="true" name="IssuedToDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_AccruedRSUDividendEquivalents" abstract="false" name="AccruedRSUDividendEquivalents" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsVestedinPeriodWeightedAverageVestDateFairValue" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsVestedinPeriodWeightedAverageVestDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_PerformanceAdjustmentAccruedPSUDividendEquivalents" abstract="false" name="PerformanceAdjustmentAccruedPSUDividendEquivalents" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOtherAdjustmentsInPeriodWeightedAverageGrantDateFairValue" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOtherAdjustmentsInPeriodWeightedAverageGrantDateFairValue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="agnc_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOtherAdjustmentsInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOtherAdjustmentsInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_DeferredSharesOutstanding" abstract="false" name="DeferredSharesOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_EquityIncentivePlansAbstract" abstract="true" name="EquityIncentivePlansAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="agnc_MTGEIncentivePlanMember" abstract="true" name="MTGEIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="agnc_PerformanceadjustmentPSUGrant" abstract="false" name="PerformanceadjustmentPSUGrant" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="agnc_ShareBasedCompensationArrangementBySharebasedPaymentAwardAwardEstimatedVestingRightsPercentage" abstract="false" name="ShareBasedCompensationArrangementBySharebasedPaymentAwardAwardEstimatedVestingRightsPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardActualVestingRights" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardActualVestingRights" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="agnc_TaxCharacterizationAxis" abstract="true" name="TaxCharacterizationAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="agnc_TaxCharacterizationDomain" abstract="true" name="TaxCharacterizationDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
